Time and cell specific regulation of NF-κB subunit specific signalling pathways terminating inflammation in immunological systems

Summary

Sequential and cell-specific activation of different subunits of the transcription factor NF-kB and the combination of these subunits allows for the coordinated activation of gene clusters required for the cellular inflammatory and immune response. Yet only little is known about the signaling cascades involved in the differential activation of the different NF-kB subunits, their cell specificity and their effects on gene expression and termination of the inflammatory response. Within this proposal, we therefore aim to identify the temporal, spatial and cell-specific signaling pathways underlying the NF-kB-subunit mediated resolution of inflammation

Publications (5 selected publication related to the proposal)  

Djuric, Z., K. Laine, S. Murikinati, C. Ehrmann, D. Piel, Y. Seregin, R. von Bauer, F. Bea, B.  Isermann, M. Zeier, H. C.  Liou, M. Pizzi, P.M. Humpert, M. Schwaninger, P.P. Nawroth, and A. Bierhaus; 2011. Targeting NF-κB subunit-specific activation pathways for prevention of atherothrombosis. Submitted.

Gebhardt, C., A. Riehl, M. Durchdewald, J. Németh, G.  Fürstenberger, K. Müller-Decker, A. Enk, B. Arnold, A. Bierhaus, P. P. Nawroth, J. Hess, and P. Angel; 2008. RAGE signaling sustains inflammation and promotes tumor development. J Ex Med 205: 275-85. 

Luft, Th., E.  Maraskovsky, M. Schnur, K. Knebel, M. Kirsch, M. Görner, R. Skoda, J. Cebon, A.D. Ho, P.P.  Nawroth, and  A. Bierhaus ; 2004. Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion in dentritic cells. Blood 104: 1066-1074.

Bierhaus, A., J. Wolf, M.  Andrassy, N. Rohleder, P.M. Humpert, D. Petrov, R. Ferstl, M. von Eynatten, T. Wendt, G. Rudofsky, M. Joswig, M. Morcos, M. Schwaninger, B. McEwen, C. Kirschbaum C, and P. P. Nawroth; 2003. A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci USA 100:1920-5.

Bierhaus, A., S. Schiekofer, M. Schwaninger, M. Andrassy, P.M. Humpert, J. Chen, M. Hong, T. Luther, T. Henle, I. Klöting, M. Morcos, M. A. Hofmann, H. Tritschler, B. Weigle, M. Kasper, M. A. Smith, G. Perry, A.M. Schmidt, D. M.Stern, H.U.Häring, E. Schleicher, and P.P. Nawroth; 2001. Diabetes-associated sustained activation of the transcription factor NF-κB. Diabetes 50: 2792-2809.

SFB Group leaders 

Project leader	TP	Phone / E-Mail	Institution
Angelika BierhausD	N	+49 6221 56 4752 Angelika.Bierhaus(at)med.uni-heidelberg.de	Dept. of Medicine I & Clin.Chemistry University Heidelberg INF 410 69120 Heidelberg