Working Groups
Inflammatory signaling in gastric and esophageal cancer
The research focus of the group are the molecular mechanisms in the development and progression of gastric and esophageal cancer. The epithelium of these organs underlies a frequent regeneration that is mediated by a complex network of cytokines. The specific focus of our group is the role of angiogenic and inflammatory cytocines in the carcinogenesis and in the clinical relevance of the research results. The long-term goal of our research is to improve the therapy and prognosis of these diseases in particular by translational studies. For this purpose, we combine cell culture and animal experiments with analysis of clinical samples and data. By this close network of clinical and basic science research within the research group, we provide excellent conditions for medical and master students.
Most relevant publications
Nienhüser H, Kim W, Malagola E, Ruan T, Valenti G, Middelhoff M, Bass A, Der CJ, Hayakawa Y, Wang TC. Mist1+ gastric isthmus stem cells are regulated by Wnt5a and expand in response to injury and inflammation in mice. Gut Jul 2020 24;gutjnl-2020-320742
Middelhoff M*, Nienhüser H*, Valenti G, Maurer HC, Hayakawa Y, Takahashi R, Kim W, Jiang Z, Malagola E, Cuti K, Tailor Y, Zamechek LB, Renz BW, Quante M, Yan KS, Wang TC.Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche. Nat Commun. 2020 Jan 8;11(1):111. *equal contribution
Nienhüser H, Crnovrsanin N, Nerz D, Heckler M, Sisic L, Lasitschka F, Schneider M, Schmidt T J. Expression of Angiogenic Proteins in Tumor and Stroma Affects Survival in Patients With Gastric Cancer. Surg Res. 2020 Jun 18;255:172-180.
Research Images
