2025-Cell Reports Medicine

Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

Li H, Zhang Z, Shi Z, Zhou S, Nie S, Yu Y, Zhang L, Sun Y, Fang C, Hu J, Niu Y, Schuck K, Wang L, Jiang K, Lu Z, Kahlert C, Roth S, Loos M, Herr I, Sunami Y, Kleeff J, Friess H, Reichert M, Dantes Z, Zou X, Michalski CW, Shen S, Kong B.

2025-International Journal of Cancer

ARP2/3 complex affects myofibroblast differentiation and migration in pancreatic ductal adenocarcinoma.

Sun Y, Qiao Y, Niu Y, Madhavan BK, Fang C, Hu J, Schuck K, Traub B, Friess H, Herr I, Michalski CW, Kong B.

2021-Gastroenterology

AGR2-dependent nuclear import of RNA polymerase II constitutes a specific target of pancreatic ductal adenocarcinoma in the context of wild-type p53.

Zhang Z, Li H, Deng Y, Schuck K, Raulefs S, Maeritz N, Yu Y, Hechler T, Pahl A, Fernández-Sáiz V, Wan Y, Wang G, Engleitner T, Öllinger R, Rad R, Reichert M, Diakopoulos KN, Weber V, Li J, Shen S, Zou X, Kleeff J, Mihaljevic A, Michalski CW, Algül H, Friess H, Kong B.

2021-Gastroenterology

mTORC1 and mTORC2 converge on the Arp2/3 complex to promote Kras G12D-induced acinar-to-ductal metaplasia and early pancreatic carcinogenesis.

Zhao Y, Schoeps B, Yao D, Zhang Z, Schuck K, Tissen V, Jäger C, Schlitter AM, van der Kammen R, Ludwig C, D'Haese JG, Raulefs S, Maeritz N, Shen S, Zou X, Krüger A, Kleeff J, Michalski CW, Friess H, Innocenti M, Kong B.

2019- International Journal of Cancer

Ductal obstruction promotes formation of preneoplastic lesions from the pancreatic ductal compartment.

Cheng T, Zhang Z, Jian Z, Raulefs S, Schlitter AM, Steiger K, Maeritz N, Zhao Y, Shen S, Zou X, Ceyhan GO, Friess H, Kleeff J, Michalski CW, Kong B.

2018- Cellular and Molecular Gastroenterology and Hepatology

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma.

Jian Z, Cheng T, Zhang Z, Raulefs S, Shi K, Steiger K, Maeritz N, Kleigrewe K, Hofmann T, Benitz S, Bruns P, Lamp D, Jastroch M, Akkan J, Jäger C, Huang P, Nie S, Shen S, Zou X, Ceyhan GO, Michalski CW, Friess H, Kleeff J, Kong B.

2018 - Gut

Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy.

Kong B, Bruns P, Behler NA, Chang L, Schlitter AM, Cao J, Gewies A, Ruland J, Fritzsche S, Valkovskaya N, Jian Z, Regel I, Raulefs S, Irmler M, Beckers J, Friess H, Erkan M, Mueller NS, Roth S, Hackert T, Esposito I, Theis FJ, Kleeff J, Michalski CW.

2016-Oncogenesis

In vivo functional dissection of a context-dependent role for Hif1α in pancreatic tumorigenesis.

Cheng T, Jian Z, Li K, Raulefs S, Regel I, Shen S, Zou X, Ruland J, Ceyhan GO, Friess H, Michalski CW, Kleeff J, Kong B.

2016- Gut

A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling.

Kong B, Wu W, Cheng T, Schlitter AM, Qian C, Bruns P, Jian Z, Jäger C, Regel I, Raulefs S, Behler N, Irmler M, Beckers J, Friess H, Erkan M, Siveke JT, Tannapfel A, Hahn SA, Theis FJ, Esposito I, Kleeff J, Michalski CW.

2015-Molecular Cancer

Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma.

Kong B, Cheng T, Qian C, Wu W, Steiger K, Cao J, Schlitter AM, Regel I, Raulefs S, Friess H, Erkan M, Esposito I, Kleeff J, Michalski CW.

2015- International Journal of Surgery 

Metabolism gene signatures and surgical site infections in abdominal surgery.

Kong B, Bruns P, Raulefs S, Rieder S, Paul L, Prazeresda Costa O, Buch T, Theis FJ, Michalski CW, Kleeff J.

2011- Nature Reviews Gastroenterology & Hepatology

From tissue turnover to the cell of origin for pancreatic cancer.

Kong B, Michalski CW, Erkan M, Friess H, Kleeff J.

2010-Oncogene

AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-β-mediated ERK signaling.

Kong B, Michalski CW, Hong X, Valkovskaya N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito I, Friess H, Kleeff J.