Apoptose und Lebererkrankungen - therapeutische Interferenz
AG Müller-Schilling
Kontakt
Ausgewählte Publikationen
1. Strand S., Hofmann W.J., Hug H., Müller M., Otto G., Strand D., Mariani S., Stremmel W., Krammer P.H., Galle P.R. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells- a mechanism of immune evasion? Nature Med 2, 12, 1361-66 (1996).
2. Müller M., Strand S., Hug H., Heinemann E.-M., Walczak H., Hofmann W.J., Stremmel W., Krammer P.H., Galle P.R. Drug-induced apoptosis in hepatoma cells is medi¬ated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J Clin Invest 99: 403-413 (1997).
3. Müller M., Wilder S., Bannasch D., Israeli D., Lehlbach K., Weber M.L, Friedman S., Galle P.R., Stremmel W., Oren M., Krammer P.H. p53 activates the CD95 (APO-1/FAS) gene in response to DNA damage by anticancer drugs. J Exp Med; 188(11): 2033-2045 (1998).
4. Eichhorst S.T., Müller M., Li-Weber M., Schulze-Bergkamen H., Krammer P.H.: A novel AP-1 element in the CD95 ligand promotor is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol Cell Biol., 2000, 20(20) 7826 – 7837.
5. Gressner O., Schilling T., Lorenz K., Schulze-Schleithoff E., Koch A., Schulze-Bergkamen H., Maria Lena A., Candi E., Terrinoni A., Valeria Catani M., Oren M., Melino G., Krammer P.H., Stremmel W., Müller M. TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO Journal, 24: 2458-2471 (2005).
6. Müller M., Schilling T., Sayan AE., Kairat A., Lorenz K., Schulze-Bergkamen H., Oren M., Koch A., Tannapfel A., Stremmel W., Melino G., Krammer PH. TAp73/DeltaNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death & Differ, 12: 1564-1577 (2005).
7. Kern M.A., Haugg A., Koch A., Schilling T., Breuhahn K., Walczak H., Fleischer B., Trautwein C., Michalski C., Schulze-Bergkamen H., Friess H., Stremmel W., Krammer P.H., Schirmacher P., Müller M. Cyclooxygenase (COX)-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res, 66 (14): 7059-66 (2006).
8. Gagiannis S.*, Müller M.*, Uhlemann S., Koch A., Melino G., Krammer P. H., Nawroth P. P., Brune M., Schilling T. Parathyroid-hormone related Protein (PTHrP) confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria. Int. J. Cancer, 2009, 125(7):1551-7. * equal contribution
9. Schilling T., Schulze Schleithoff E., Kairat A., Melino G., Stremmel W., Oren M., Krammer P.H., Müller M. Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family. Biochem Biophys Res Commun, 2009, 387:399-404.
10. Seitz S.J., Schulze Schleithoff E., Koch A., Schuster A., Teufel A., Staib F., Stremmel W., Melino G., Krammer P.H.,Schilling T., Müller M. Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int. J. Cancer, 2010, 126(9):2049-66.
11. Schuster A., Schilling T., De Laurenzi V., Koch A., Seitz S., Staib F., Teufel A., Thor-geirsson S.S., Galle P.R., Melino G., Stremmel W., Krammer P.H., Müller M. ΔNp73ß is oncogenic in hepatocellular carcinoma by blocking apoptosis signaling via death re-ceptors and mitochondria. Cell Cycle 2010, Jul 16;9(13):2629-2639.