Journal Club - Basket Trials and Innovative Study Designs

Basket trials are a type of clinical trial in which the efficacy or safety of a new treatment is investigated simultaneously in several patient subgroups. They are mostly used in early phase clinical trials in oncology. These trials include patients with different tumor histologies but a common genetic target. The underlying assumption of these trials is therefore that the presence of the genetic feature is more important for the efficacy of the treatment than the histology or the location of the primary tumor.

In this journal club, participants present and discuss methodological publications on basket trial designs and on related innovative trial designs. Each participant will present one or two papers from the methodological literature in a 50 minute talk. Subsequently there will be time for questions and for discussing advantages, limitations and applications of the presented method.

This journal club is intended for PhD students and researchers with a strong background in mathematics or statistics who are interested in statistical methods for the analysis of basket trials.

Course dates: A preliminary meeting will be held on April 4th, 2025, 13:45. Presentations will be given weekly, starting on April 22nd. Later course entry is possible. The last presentation is planned to take place on July 1st. 

Please register by e-mail: lehranmeldung(at)imbi.uni-heidelberg.de.

Further information
Lukas Baumann
Tel.: 06221 – 56 6594
E-Mail: baumann(at)imbi.uni-heidelberg.de