GLIO-CAVE Studie
Adjuvant stereotactic fractionated radiotherapy to the resection cavity in recurrent glioblastomas
Einschlusskriterien
- Unifocal recurrence of a supratentorial glioma
- HighGrade Glioma at recurrence
- Prior course of standard treatment (40 – 66 Gy, depending on fractionation concept)
- Complete resection of all contrast enhancing tumor areas at recurrence
- age ≥ 18 years of age
- Karnofsky Performance Score ≥ 60%
- For women with childbearing potential, (and men) adequate contraception.
- Ability of subject to understand character and individual consequences of the clinical trial
- Written informed consent (must be available before enrolment in the trial)
Ausschlusskriterien
- Distant multifocal glioblastoma of gliomatosis cerebri
- Time interval of less than 6 months after primary radiotherapy
- Previous re-irradiation or prior radiosurgery of prior treatment with interstitial radioactive seeds
- refusal of the patients to take part in the study
- Known carcinoma (excluding Carcinoma in situ of the cervix, basal cell carcinoma, squamous cell carcinoma of the skin) requiring immediate treatment interfering with study therapy
- Pregnant or lactating women
- Participation in another clinical study or observation period of competing trials, respectively