Recent Publications

For a complete and current publication list please check the following links:

Mirko Cortese, Ji Young Lee, Berati Cerikan, Christopher J. Neufeldt, Viola M.J. Oorschot, Sebastian Köhrer, Julian Hennies, Nicole L. Schieber, Paolo Ronchi, Giulia Mizzon, Inés Romero-Brey, Rachel Santarella-Mellwig, Martin Schorb, Mandy Boermel, Karel Mocaer, Marianne S. Beckwith, Rachel M. Templin, Viktoriia Gross, Constantin Pape, Christian TischerWeniger anzeigenJamie Frankish, Natalie K. Horvat, Vibor Laketa, Megan Stanifer, Steeve Boulant, Alessia Ruggieri, Laurent Chatel-Chaix, Yannick Schwab, Bartenschlager R.
Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies.
Cell Host Microbe 2020 Dec 9;28(6):853-866.e5. doi: 10.1016/j.chom.2020.11.003.

Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R.
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.
Cell Host Microbe. 2011 Jan 20;9(1):32-45.

Welsch S, Miller S, Romero-Brey I, Merz A, Bleck CK, Walther P, Fuller SD, Antony C, Krijnse-Locker J, Bartenschlager R.
Composition and three-dimensional architecture of the dengue virus replication and assembly sites.
Cell Host Microbe. 2009 Apr 23;5(4):365-75. doi: 10.1016/j.chom.2009.03.007.Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Kräusslich HG, Mizokami M,

Wakita T*, Pietschmann T*, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Kräusslich HG, Mizokami M, Bartenschlager R*, Liang TJ. (* equal contribution)
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome.
Nat Med. 2005 Jul;11(7):791-6.

Lohmann V, Körner F, Koch J, Herian U, Theilmann L, Bartenschlager R.
Replication of subgenomic HCV RNAs in a hepatoma cell line.
Science. 1999 Jul 2;285(5424):110-3.

Willemsen, J., Wicht, O., Wolanski, J.C., Baur, N., Bastian, S., Haas, D.A., Matula, P., Knapp, B., Meyniel-Schicklin, L., Wang, C., Bartenschlager, R., Lohmann, V., Rohr, K., Erfle, H., Kaderali, L., Marcotrigiano, J., Pichlmair, A. and Binder, M. (2017)
Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening
Molecular Cell 65 (3):403–415

Pichlmair, A, Kandasamy, K, Alvisi, G, Mulhern, O, Sacco, R, Habjan,M, Binder, M, Stefanovic, A, Eberle, C.-A, Goncalves, A, Bürckstümmer, T, Müller, A.C, Fauster, A, Holze, C, Lindsten, K, Goodbourn, S, Kochs, G, Weber, F, Bartenschlager, R, Bowie, A.G, Bennett, K.L, Colinge, J, and Superti-Furga, G (2012).
Viral immune modulators perturb the human molecular network by common and unique strategies.
Nature, 487, 486–490

Binder, M, Eberle, F, Seitz, S, Mücke, N, Hüber, C. M, Kiani, N, Kaderali L., Lohmann V, Dalpke A, Bartenschlager R (2011).
Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).
The Journal of Biological Chemistry, 286(31), 27278–27287

Binder M, Kochs G, Bartenschlager R, Lohmann V., (2007).
Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy.
Hepatology. 2007 Nov;46(5):1365-74.

Meylan, E., Curran, J, Hofmann, K, Moradpour, D, Binder, M, Bartenschlager, R, & Tschopp, J (2005).
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Nature, 437(7062), 1167–1172

Harak C, Meyrath M, Romero-Brey I, Schenk C, Gondeau C, Schult P, Esser-Nobis
K, Saeed M, Neddermann P, Schnitzler P, Gotthardt D, Perez-Del-Pulgar S,
Neumann-Haefelin C, Thimme R, Meuleman P, Vondran FW, Francesco R, Rice CM,
Bartenschlager R, Lohmann V.
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

Direct Link to e-Publication (e-Mail address required)

Nat Microbiol.2:16247. doi: 10.1038/nmicrobiol.2016.247.

Esser-Nobis K, Schmidt J, Nitschke K, Neumann-Haefelin C, Thimme R, Lohmann V.
The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby
promoting antigen-specific CD8(+) T cell activation.
J Hepatol.64(6):1305-14, 2016.

Esser-Nobis K, Harak C, Schult P, Kusov Y, Lohmann V.
Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication.
Hepatology 62:397-408, 2015

Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V.
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.
PLoS Pathog 9:e1003359, 2013.

Lohmann V, Körner F, Koch J, Herian U, Theilmann L, Bartenschlager R.
Replication of subgenomic HCV RNAs in a hepatoma cell line.
Science. 1999 Jul 2;285(5424):110-3.

Poenisch M, Metz P, Blankenburg H, Ruggieri A, Lee JY, Rupp D, Rebhan I, Diederich K, Kaderali L, Domingues FS, Albrecht M, Lohmann V, Erfle H, Bartenschlager R.
Identification of HNRNPK as regulator of hepatitis C virus particle production.
PLoS Pathog. 2015 Jan 8;11(1):e1004573. doi: 10.1371/journal.ppat.1004573. eCollection 2015 Jan.

Manvar D, Pelliccia S, La Regina G, Famiglini V, Coluccia A, Ruggieri A, Anticoli S, Lee JC, Basu A, Cevik O, Nencioni L, Palamara AT, Zamperini C, Botta M, Neyts J, Leyssen P, Kaushik-Basu N, Silvestri R.
New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2.
Eur J Med Chem. 2015 Jan 27;90:497-506. doi: 10.1016/j.ejmech.2014.11.042. Epub 2014 Nov 27.

Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V.
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.
PLoS Pathog. 2013 May;9(5):e1003359. doi: 10.1371/journal.ppat.1003359. Epub 2013 May 9.

Ruggieri A, Anticoli S, Nencioni L, Sgarbanti R, Garaci E, Palamara AT.
Interplay between Hepatitis C Virus and Redox Cell Signaling.
Int J Mol Sci. 2013 Feb 26;14(3):4705-21. doi: 10.3390/ijms14034705.

Ruggieri A, Dazert E, Metz P, Hofmann S, Bergeest JP, Mazur J, Bankhead P, Hiet MS, Kallis S, Alvisi G, Samuel CE, Lohmann V, Kaderali L, Rohr K, Frese M, Stoecklin G, Bartenschlager R.
Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection.
Cell Host Microbe. 2012 Jul 19;12(1):71-85. doi: 10.1016/j.chom.2012.05.013.

Schulze A, Mills K, Weiss TS, Urban S.
Hepatocyte polarization is essential for the productive entry of HBV.
J Hepatology. 2012; 55(2):373-83.

Petersen J, Dandri M, Mier W, Lütgehetmann M, Volz T, von Weizsäcker F, Haberkorn U, Fischer L, Pollok JM, Erbes B, Seitz S, Urban S.
Prevention of HBV infection in vivo by entry inhibitors derived from the large envelope protein.
Nat Biotechnol. 2008 Mar; 26(3):335-341.

Seitz S, Urban S, Antoni C, Bottcher B.
Cryo-electron microscopy of hepatitis B virion reveals variability in envelope capsid interactions.
EMBO J 2007 Sep 19; 26(18):4160-4167.

Gripon P, Cannie I, Urban S.
Efficient inhibition of HBV infection by acylated peptides derived from the large viral surface protein.
J Virol. 2005 Feb;79(3):1613-1622.

Gripon P, Rumin S, Urban S, Le Seyec J, Glaise D, Cannie I, Guyomard C, Lucas J, Trepo C, Guguen-Guillouzo C.
Infection of a human hepatoma cell line by HBV.
PNAS 2002 Nov 26; 99(24):15655-15660.

Recent Publications

- The 5 most important publications of Ralf Bartenschlager and his group:

- The 5 most important publications of Marco Binder and his group:

- The 5 most important publications of Volker Lohmann and his group:

- The 5 most important publications of Alessia Ruggieri and her group:

- The 5 most important publications of Stephan Urban and his group: