Universitätsklinikum Heidelberg: Selected Articles & Selected Reviews

AG Bartenschlager

Vassilaki N, Friebe P, Meuleman P, Kallis S, Kaul A, Paranhos-Baccalà G, Leroux-Roels G, Mavromara P, Bartenschlager R., 2008
Role of Hepatitis C Virus Core+1 Open Reading Frame and Core Cis-Acting RNA Elements in Viral RNA Translation and Replication. J Virol. 2008 Sep 17. [Epub ahead of print]

Jirasko V, Montserret R, Appel N, Janvier A, Eustachi L, Brohm C, Steinmann E, Pietschmann T, Penin F, Bartenschlager R., 2008
Structural and functional characterization of non-structural protein 2 for its role in hepatitis C virus assembly. J Biol Chem. 2008 Oct 17;283(42):28546-28562. Epub 2008 Jul 21.

Steinmann E, Brohm C, Kallis S, Bartenschlager R, Pietschmann T., 2008
Efficient Trans-Encapsidation of Hepatitis C Virus RNAs into Infectious Virus-like Particles. J Virol. 2008 Jul;82(14):7034-46. Epub 2008 May 14.

Bartenschlager R, Miller S., 2008
Molecular aspects of Dengue virus replication. Future Microbiol. 2008 Apr;3:155-65.

Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, Kallis S, Engel U, Bartenschlager R., 2008
Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly.PLoS Pathog. 2008 Mar 28;4(3)

Scholtes C, Diaz O, Icard V, Kaul A, Bartenschlager R, Lotteau V, André P., 2008
Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR. J Hepatol. 2008 Feb;48(2):192-9. Epub 2007 Dec 3.

Zeisel MB, Koutsoudakis G, Schnober EK, Haberstroh A, Blum HE, Cosset FL, Wakita T, Jaeck D, Doffoel M, Royer C, Soulier E, Schvoerer E, Schuster C, Stoll-Keller F, Bartenschlager R, Pietschmann T, Barth H, Baumert TF., 2007
Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81. Hepatology. 2007 Dec;46(6):1722-31.

Shavinskaya A, Boulant S, Penin F, McLauchlan J, Bartenschlager R., 2007.
The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly. J Biol Chem. 2007 Oct 17 [Epub ahead of print]

Kaul A, Woerz I, Meuleman P, Leroux-Roels G, Bartenschlager R., 2007.
Cell culture adaptation of hepatitis C virus and in vivo viability of an adapted variant. J Virol. 2007 Dec;81(23):13168-79. Epub 2007 Sep 19.

Binder M, Kochs G, Bartenschlager R, Lohmann V., 2007.
Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology. 2007 Nov;46(5):1365-74.

Miyanari Y, Atsuzawa K, Usuda N, Watashi K, Hishiki T, Zayas M, Bartenschlager R, Wakita T, Hijikata M, Shimotohno K., 2007.
The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol. 2007 Sep;9(9):1089-97.

Bartenschlager R, Sparacio S., 2007.
Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture. Virus Res. 2007 Aug;127(2):195-207.

Steinmann E, Penin F, Kallis S, Patel AH, Bartenschlager R, Pietschmann T., 2007.
Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions. PLoS Pathog. 2007 Jul 20;3(7)

Steinmann E, Whitfield T, Kallis S, Dwek RA, Zitzmann N, Pietschmann T, Bartenschlager R. 2007.
Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. Hepatology. 2007 Jun 28;46(2):330-338

Binder M, Quinkert D, Bochkarova O, Klein R, Kezmic N, Bartenschlager R, Lohmann V. 2007.
Identification of determinants involved in initiation of hepatitis C virus RNA synthesis by using intergenotypic replicase chimeras. J Virol. 2007 May;81(10):5270-83. Epub 2007 Mar 7.

Schaller T, Appel N, Koutsoudakis G, Kallis S, Lohmann V, Pietschmann T, Bartenschlager R. 2007.
Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. Journal of Virology, 2007 Feb 14; Epub 2007 Feb 14.

Miller S, Kastner S, Krijnse-Locker J, Buhler S, Bartenschlager R. 2007.
Non-structural protein 4A of Dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner.J Biol Chem. 2007 Feb 2; Epub 2007 Feb 2.

Combet C, Garnier N, Charavay C, Grando D, Crisan D, Lopez J, Dehne-Garcia A, Geourjon C, Bettler E, Hulo C, Le Mercier P, Bartenschlager R, Diepolder H, Moradpour D, Pawlotsky JM, Rice CM, Trepo C, Penin F, Deleage G. 2007.
euHCVdb: the European hepatitis C virus database. Nucleic Acids Res. 2007 Jan;35(Database issue):D363-6. Epub 2006 Nov 16.

Dreux,M., Pietschmann,T., Granier,C., Voisset,C., Ricard-Blum,S., Mangeot,P.E., Keck,Z., Foung,S., Vu-Dac,N., Dubuisson,J., Bartenschlager,R., Lavillette,D., Cosset,F.L., 2006.
High density lipoprotein inhibits hepatitis C virus neutralising antibodies by stimulating cell entry via activation of the scavenger receptor BI. J Biol Chem. 2006 Jul 7;281(27):18285-95.

Koutsoudakis, G., A. Kaul, E. Steinmann, S. Kallis, V. Lohmann, T. Pietschmann, and R. Bartenschlager, 2006.
Characterization of the early steps of Hepatitis C virus infection by using luciferase reporter viruses. J Virol. 2006 Jun;80(11):5308-20.

Pietschmann,T., Kaul,A., Koutsoudakis,G., Shavinskaya,A., Kallis,S., Steinmann,E., Abid,K., Negro,F., Dreux,M., Cosset,F.L., Bartenschlager,R, 2006.
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7408-13.

Appel N, Bartenschlager R., 2006.
A novel function for a micro RNA: negative regulators can do positive for the hepatitis C virus. Hepatology. 2006 Mar;43(3):612-5.

Miller S, Sparacio S, Bartenschlager R., 2006.
Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B. J Biol Chem. 2006 Mar 31;281(13):8854-63.

Appel N, Schaller T, Penin F, Bartenschlager R., 2006.
From structure to function: new insights into hepatitis C virus RNA replication. J Biol Chem. 2006 Apr 14;281(15):9833-6.

Meylan, E., J. Curran, K. Hofmann, D. Moradpour, M. Binder, R. Bartenschlager and J. Tschopp. 2005.
Cardif is a novel adaptor protein in RIG-I-mediated antiviral responses targeted by hepatitis C virus. Nature, 437:1167-1172.

Windisch, M., M. Frese, A. Kaul, M. Trippler, V. Lohmann, and R. Bartenschlager. 2005.
Dissecting the Interferon-Induced Inhibition of Hepatitis C Virus Replication by Using a Novel Host Cell Line. Journal of Virology, 79:13778-13793.

Wakita, T.*, T. Pietschmann*, T. Kato, T. Date, M. Miyamoto, Z. Zhao, K. Murthy, A. Habermann, H.-G. Kräusslich, M. Mizokami, R. Bartenschlager*, and T.J. Liang. 2005.
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nature Medicine, 11:791-796. * Equal contribution.

Quinkert, D., R. Bartenschlager, and V. Lohmann, 2005.
Quantitative analysis of the hepatitis C virus replication complex. Journal of Virology, 79:13594-13605..

Appel, N., T. Pietschmann, and R. Bartenschlager. 2005.
Mutation analysis of hepatitis C virus nonstructural protein 5A: Potential role of differential phosphorylation for RNA replication and identification of a genetically flexible domain. Journal of Virology, 79:3187-3194.

Appel, N., U. Herian, and R. Bartenschlager. 2005.
Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A. Journal of Virology, 79:896-909.

Friebe, P., J. Boudet, J.-P. Simorre, and R. Bartenschlager. 2005.
A kissing loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication. Journal of Virology, 79:380-392.

Krönke, J., R. Kittler, F. Buchholz, M. Windisch, T. Pietschmann, R. Bartenschlager, and M. Frese. 2004.
Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs. Journal of Virology, 78:3436-3446.

Lohmann, V., S. Hoffmann, U. Herian, F. Penin and R. Bartenschlager. 2003.
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. Journal of Virology 77:3007-3019.

Friebe, P. and R. Bartenschlager. 2002.
Genetic analysis of sequences in the 3' nontranslated region of hepatitis C virus that are important for RNA replication. Journal of Virology 76:5326-5338.

Pietschmann, T., V. Lohmann, A. Kaul, N. Krieger, G. Rinck, G. Rutter, D. Strand und R. Bartenschlager. 2002.
Persistent and transient replication of full-length hepatitis C virus genomes in cell culture. Journal of Virology, 76:4008-4021.

Frese, M., V. Schwärzle, K. Barth, N. Krieger, V. Lohmann, S. Mihm, O. Haller und R. Bartenschlager. 2002.
Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs. Hepatology, 35:694-703.

Friebe, P., V. Lohmann, N. Krieger and R. Bartenschlager. 2001.
Sequences in the 5' non-translated region of the hepatitis C virus required for RNA replication. Journal of Virology, 75:12047-12057.

Krieger, N., V. Lohmann and R. Bartenschlager. 2001.
Enhancement of hepatitis C virus RNA replication by cell culture adaptive mutations. Journal of Virology, 75:4614-4624.

Lohmann, V., F. Körner, A. Dobierzewska and R. Bartenschlager. 2001.
Mutations in hepatitis C virus RNAs conferring cell culture adaptation. Journal of Virology, 75:1437-1449.

Pietschmann, T., V. Lohmann, G. Rutter, K. Kurpanek and R. Bartenschlager. 2001.
Characterization of cell lines carrying self-replicating hepatitis C virus RNAs. Journal of Virology, 75:1252-1264.

Frese, M., T. Pietschmann, D. Moradpour, O. Haller and R. Bartenschlager. 2001.
Interferon-alpha Inhibits Hepatitis C virus Subgenomic RNA Replication by an MxA-Independent Pathway. Journal of General Virology, 82:723-733.

Lohmann, V., F. Körner, J.O. Koch, U. Herian, L. Theilmann and R. Bartenschlager. 1999.
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science, 285:110-113.

Koch, J.O. and R. Bartenschlager. 1999.
Modulation of hepatitis C virus NS5A hyperphosphorylation by NS3, NS4A and NS4B. Journal of Virology, 73:7138-7146.

Lohmann, V., H. Overton and R. Bartenschlager. 1999.
Selective Stimulation of Hepatitis C Virus and Pestivirus NS5B RNA Polymerase Activity by GTP. Journal of Biological Chemistry, 274:10807-10815.

Lohmann, V., F. Körner, U. Herian and R. Bartenschlager. 1997.
Biochemical properties of hepatitis C virus RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. Journal of Virology, 71:8416-8428.

Bartenschlager, R., V. Lohmann, T. Wilkinson and J. O. Koch. 1995.
Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation. Journal of Virology, 69:7519-7528.

Bartenschlager, R. 2006.
Hepatitis C virus molecular clones: from cDNA to infectious virus particles in cell culture. Curr Opin Microbiol. 2006 Jun 28.

Appel, N., Schaller T., Penin F., and Bartenschlager R. 2006.
From Structure to Function: New Insights into Hepatitis C Virus RNA Replication. Journal of Biological Chemistry, 2006 Apr 14;281(15):9833-6.

Bartenschlager, R., and T. Pietschmann. 2005.
Efficient hepatitis C virus cell culture system: what a difference the host cell makes.Proc Natl Acad Sci U S A. 102:9739-9740.

Bartenschlager, R. 2005.
The hepatitis C virus replicon system: From basic research to clinical application. Journal of Viral Hepatitis, 43:210-6.

Bartenschlager, R., M. Frese, and T. Pietschmann. 2004.
Novel insights into hepatitis C virus replication and persistence. Advances in Virus Research, 63:71-180.

Bartenschlager, R. 2002.
Hepatitis C virus replicons: potential role for drug development. Nature Reviews Drug Discovery. 2002 Nov;1(11):911-6

Bartenschlager, R. and V. Lohmann. 2000.
Replication of hepatitis C virus. Journal of General Virology, 81:1631-1648.

Bartenschlager, R. 1999.
The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy. Journal of Viral Hepatitis, 6:165-181.