Startseite Universitätsklinikum Heidelberg
Startseite Universitätsklinikum Heidelberg Innere Medizin V: Hämatologie, Onkologie und Rheumatologie Teil des Zentrums für Innere Medizin (Krehl Klinik)
Innere Medizin V: Hämatologie, Onkologie und Rheumatologie Teil des Zentrums für Innere Medizin (Krehl Klinik)
Kliniken &… Kliniken Medizinische… Hämatologie, Onkologie… Forschung Sektion…

Neutrophil biology in health and inflammation

Neutrophils are innate immune cells with diverse roles in homeostasis and immunopathology. They are paramount for a viable defense against invading pathogens, orchestrate immune responses with other immune cells and help repair tissues. In contrast, they are strong drivers of tissue damage in immune mediated diseases. Neutrophils are currently not directly being targeted therapeutically. Our overall research agenda is aimed at developing ways to selectively intervene with pathologic neutrophil functions without compromising host defense. We work towards this goal by studying neutrophil heterogeneity in both healthy tissues as well as pathologic inflammation in humans and mice. We study neutrophils on the systems immunology level using high dimensional technologies to understand the driving forces behind their fascinating adaptation to different tissues and inflammatory conditions. We are always seeking motivated postdoctoral fellows and graduate students to join the neutrophil biology team!
 

Head of group

Portrait von Dr. med. Ricardo Grieshaber Bouyer

Dr. med. Ricardo Grieshaber Bouyer


Members

  • Dr. med. Tarik Exner (Postdoctoral fellow, Dr. rer. nat. candidate)
  • Nicole Brosch (MTA)
  • European Molecular Biology Laboratory, Molecular Medicine Partnership Unit
  • Immunological Genome Project Consortium
  • Nigrovic Lab (Boston Children’s Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, USA)
  • Rao Lab (Brigham and Women's Hospital, Harvard Medical School, Boston, USA)
  • Tuckermann Lab (Ulm University, Germany)
  • Ramming Lab (Erlangen University Hospital, Germany)
  • Wabnitz Lab (Heidelberg University, Germany)
2021

Grieshaber-Bouyer R, Radtke FA, Cunin P, Stifano G, Levescot A, Vijaykumar B, Nelson-Maney N, Blaustein RB, Monach PA, Nigrovic PA, The Immunological Genome Project Consortium. The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments. Nature Communications. 2021, in press

Kiner E, Willie E, Vijaykumar B, Chowdhary K, Schmutz H, Chandler J, Schnell A, Thakore PI, LeGros G, Mostafavi S, Mathis D, Benoist C, The Immunological Genome Project Consortium. Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.
 Nature Immunology. 2021 doi: https://doi.org/10.1038/s41590-020-00836-7
 


2020

Immunological Genome Project Consortium. ImmGen at 15. Nature Immunology. 2020 doi: 10.1038/s41590-020-0687-4.

Grieshaber-Bouyer R, Lorenz HM. Biosimilars – Opportunities and Risks. Internist (Berl). 2020 doi: 10.1007/s00108-020-00784-2

 

2019

Grieshaber-Bouyer R, Kämmerer T, Rosshirt N, Nees T, Koniezke P, Hagmann S, Tripel E, Schiltenwolf M, Kirsch J, Moradi B. Divergent mononuclear cell participation and cytokine release profiles define hip and knee osteoarthritis. J Clin Med. 2019 doi: 10.3390/jcm8101631

Grieshaber-Bouyer R, Nigrovic PA. Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease. Front. Immunol. 2019 doi: 10.3389/fimmu.2019.00346

 

2018

Grieshaber-Bouyer R, Nigrovic PA. Maestro endothelium conducts the neutrophils. Blood. 2018 132:1734-1735; doi: 10.1182/blood-2018-09-872085

 

2017

Bai M, Grieshaber-Bouyer R, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017 130(19): 2092-2100, doi: 10.1182/blood-2017-03-768507

Grieshaber-Bouyer R and Gerber C. Arthroscopic Repair of Recurrent Posterior Shoulder Subluxation after Total Shoulder Arthroplasty. JBJS Case Connect. 2017 7:e71. doi: 10.2106/JBJS.CC.17.00048

 

Conference Abstracts
2020

Radtke F, Huang F, Nigrovic P, Grieshaber-Bouyer R. A Cross-Species Map of Neutrophil Inflammatory Responses. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/a-cross-species-map-of-neutrophil-inflammatory-responses/

Huang F, Cunin P, Radtke F, Grieshaber-Bouyer R, Darbousset R, Nigrovic P. Neutrophils Transiting Through Megakaryocytes During Emperipolesis Exhibit Distinct Fates and Acquire the Capacity to Guide Other Neutrophils via MK Trails. Arthritis Rheumatol. 2020; 72 (suppl 10). 

https://acrabstracts.org/abstract/neutrophils-transiting-through-megakaryocytes-during-emperipolesis-exhibit-distinct-fates-and-acquire-the-capacity-to-guide-other-neutrophils-via-mk-trails/

Chang M, Levescot A, Nelson-Maney N, Blaustein R, Winden K, Morris A, Balu S, Wactor A, Grieshaber-Bouyer R, Wei K, Henderson L, Clark R, Rao D, Fuhlbrigge R, Nigrovic P. Resident Memory T Cells in Synovial Tissue Mediate Arthritis Flares. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/resident-memory-t-cells-in-synovial-tissue-mediate-arthritis-flares/

Grieshaber-Bouyer R, Keegan J, Nigrovic P, Lederer J, Rao D. Mass Cytometry Reveals Activation Heterogeneity of Circulating Neutrophils in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/mass-cytometry-reveals-activation-heterogeneity-of-circulating-neutrophils-in-systemic-lupus-erythematosus/

2019

Grieshaber-Bouyer R, Stifano G, Cunin P, Levescot A, Nelson-Maney N, Blaustein R, Monach P, Nigrovic PA and ImmGen Consortium. Single-Cell RNA Sequencing of Murine Neutrophils Identifies a Transcriptional Continuum (“Neutrotime”) Across Biological Compartments. Arthritis Rheumatol. 2019 71 (suppl 10). https://acrabstracts.org/abstract/single-cell-rna-sequencing-of-murine-neutrophils-identifies-a-transcriptional-continuum-neutrotime-across-biological-compartments/

Grieshaber-Bouyer R, Kämmerer T, Rosshirt N, Koniezke P, Hagmann S, Tripel E, Kirsch J, Gotterbarm T, Moradi B. Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis. Arthritis Rheumatol. 2019 71 (suppl 10). https://acrabstracts.org/abstract/divergent-mononuclear-cell-participation-and-cytokine-release-profiles-define-hip-and-knee-osteoarthritis/

2017

Grieshaber Bouyer R, Halyabar O, Levescot A, Hoyt K, Henderson L, Nigrovic P. Multiplexed Characterization of Circulating and Joint-Derived Human Neutrophils in Inflammatory Arthritis.
Arthritis Rheumatol. 2017 69 (suppl 10). https://acrabstracts.org/abstract/multiplexed-characterization-of-circulating-and-joint-derived-human-neutrophils-in-inflammatory-arthritis/

Levescot A, Nelson-Maney N, Morris A, Grieshaber Bouyer R, Lee P, Nigrovic P. Autoimmune Arthritis in IL-1 Receptor Antagonist-Deficient Mice Is Associated with a Pathogenic Conversion of Foxp3+ Regulatory T Cells into Th17 Cells. Arthritis Rheumatol. 2017 69 (suppl 10). https://acrabstracts.org/abstract/autoimmune-arthritis-in-il-1-receptor-antagonist-deficient-mice-is-associated-with-a-pathogenic-conversion-of-foxp3-regulatory-t-cells-into-th17-cells/