Diagnosis, immunpathogenesis and prognosis of Schilder's myelinoclastic diffuse sclerosis / Diagnose, Immunpathogenese und Prognose der myelinoklastischen diffusen Sklerose Schilder

Principal investigators / Projektleitung: Sven Jarius, Brigitte Wildemann

Schilder's myelinoclastic diffuse sclerosis (MDS) is an inflammatory disease of the central nervous system characterised by extensive demyelination. Our research focuses on the nosological and diagnostic differentiation of myelinoclastic diffuse sclerosis from conventional multiple sclerosis (MS) as well as on the immunopathophysiology, therapy and prognosis of MDS.

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Die myelinoklastische diffuse Sklerose Schilder (engl. Schilder's myelinoclastic diffuse sclerosis, MDS) ist durch großflächige Demyelinisierung gekennzeichnete entzündliche Erkrankung des zentralen Nervensystems. Schwerpunkt unserer Forschung sind Untersuchungen zur nosologischen und diagnostischen Abgrenzung der myelinoklastischen diffusen Sklerose von der konventionellen Multiplen Sklerose (MS), zur Immunpathophysiologie und zur Therapie und Prognose der MDS. 

Selected publications on MDS / Ausgewählte Publikationen zum Thema

• Jarius S, Haas J, Paul F, Wildemann B. Myelinoclastic diffuse sclerosis (Schilder's disease) is immunologically distinct from multiple sclerosis: results from retrospective analysis of 92 lumbar punctures. J Neuroinflammation. 2019 Feb 28;16(1):51. [FREE PDF]