Diagnosis and pathophysiology of paraneoplastic and other antibody-associated disorders (except NMOSD and MOGAD) / Diagnostik und Pathophysiologie paraneoplastischer und sonstiger Autoantikörper-assoziierter Syndrome (außer NMO und MOG-EM)

Principal investigators / Projektleiter: Sven Jarius*, Brigitte Wildemann*

This project investigates the diagnostic and pathophysiological relevance of autoantibodies and B cells in diseases of the central and/or peripheral nervous system (paraneoplastic/idiopathic cerebellar ataxia, limbic encephalitis, Susac syndrome, etc.).

Independent projects are focusing on elucidating the role of autoantibodies against aquaporin-4 (NMO-IgG/AQP4-AK) in neuromyelitis optica (NMO) and related syndromes (see here) and to the role of autoantibodies against myelin oligodendrocyte glycoprotein (MOG) in demyelinating diseases of the CNS (see here), respectively.

Gegenstand unserer Forschung ist die diagnostische und pathophysiologische Relevanz von Autoantikörpern und B-Zellen bei Erkrankungen des zentralen und/oder peripheren Nervensystems (paraneoplastische/idiopathische zerebelläre Ataxie, limbische Enzephalitis, Susac-Syndrom u.a.).

Eigenständige Projektbereiche sind der Rolle von Autoantikörpern gegen Aquaporin-4 (NMO-IgG/AQP4-AK) bei Neuromyelitis optica (NMO) und verwandten Syndromen (siehe hier) sowie der Rolle von Autoantikörpern gegen Myelin-Oligodendrozyten-Glykoprotein (MOG) bei demyelinisierenden Erkrankungen des ZNS (siehe hier) gewidmet.

_{^{* Brigitte Wildemann (h-index 68 / 18300 citations [according to Publish or Perish 7.33; data last retrieved 2023-06-20]) is Professor of Neurology and Head of the Molecular Neuroimmunology Group in the Department of Neurology, University of Heidelberg, Germany. Her research goals focus on the immunopathogenesis of multiple sclerosis (MS). Other research interests are neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease/encephalomyelitis (MOGAD/MOG-EM), acute disseminated encephalomyelitis (ADEM), autoimmune encephalitis, and the pathogenetic mechanisms involved in the neuromanifestations of systemic diseases, such as rheumatological disorders and HIV/AIDS. She has authored/co-authored more than 250 peer-reviewed articles and numerous book chapters, has published as lead editor the Thieme standard textbook "Laboratory Diagnosis in Neurology", and is co-author of the German guidelines on MS, NMOSD, MOGAD/MOG-EM, of the German guidelines on CSF analysis, and of the National Recommendation for the use of autologous hematopoietic stem cell transplantation (aHSCT) in MS is in Germany. Brigitte Wildemann is also current president of the German Society for CSF Analysis and Clinical Neurochemistry (DGLN).}}

_{^{Sven Jarius (h-index 77 / 26121 citations [according to Publish or Perish 7.33; data last retrieved 2024-09-15]) is a senior scientist in the field of clinical and basic neuroimmunology who has trained at the Institute of Clinical Neuroimmunology and the Department of Neurology, Ludwig Maximilian University, Munich, Germany, in the Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried/Munich, Germany, and in the Neurosciences Group at the Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, UK. His main topics of interest are neuromyelitis optica spectrum disorders (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease/encephalomyelitis (MOGAD/MOG-EM); multiple sclerosis; autoimmune encephalitis, myelitis, and optic neuritis; autoimmune cerebellar ataxia; paraneoplastic neurological syndromes; and the history of neuroscience. Since 2008 he has worked at the Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Germany.  He is lead author or co-author, respectively, of several international diagnostic consensus criteria (NMOSD, MOGAD/MOG-EM, Susac syndrome, primary autoimmune cerebellar ataxia) and first described/was involved in the first description and/or clincal definition of several novel autoimmune disorders. He has published around 240 peer-reviewed articles, including in Nat Rev Dis Primers (5-year IF 93), Nat Rev Neurol (5-year IF 44), Nat Rev Clin Pract, Lancet Neurology, BMJ, Brain, Neurology, Ann Neurol, Arch Neurol, J Neurol, J Neurol Neurosurg Psychiatry, Eur J Neurol, Front Neurol, Curr Opin Neurol, Neurology:Neuroimmunol Neuroinflamm, Acta Neuropathol, Brain Pathol, J Neuroinflammation, J Neuroimmunology, J Immununology, Front Immunol, Adv Immunol, J Autoimmunity, MSJ, MSARD, Arthritis & Rheumatism, and Blood.}}

Selected publication / Ausgewählte Publikationen zum Thema

• Miske R, Scharf M, Borowski K, Rieckhoff N, Teegen B, Denno Y, Probst C, Guthke K, Didrihsone I, Wildemann B, Ruprecht K, Komorowski L, Jarius S. Septin-3 autoimmunity in patients with paraneoplastic cerebellar ataxia. J Neuroinflammation 2023 Mar 30;20(1):88.
• Huth A, Ayoub I, Barateau L, Gerdes LA, Severac D, Krebs S, Blum H, Tumani H, Haas J, Wildemann B, Kümpfel T, Beltrán E, Liblau RS, Dauvilliers Y, Dornmair K. Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy. J Autoimmun. 2024 Jun;146:103234.
• Greguletz P, Plötz M, Baade-Büttner C, Bien CG, Eisenhut K, Geis C, Handreka R, Klausewitz J, Körtvelyessy P, Kovac S, Kraft A, Lewerenz J, Malter M, Nagel M, von Podewils F, Prüß H, Rada A, Rau J, Rauer S, Rößling R, Seifert-Held T, Siebenbrodt K, Sühs KW, Tauber SC, Thaler F, Wagner J, Wickel J, Leypoldt F, Rittner HL, Sommer C, Villmann C, Doppler K; GENERATE study group. Different pain phenotypes are associated with anti-Caspr2 autoantibodies. J Neurol. 2024 May;271(5):2736-2744. 
• Jarius S, Haas J, Wildemann B. Rho GTPase-activating protein 17 (ARHGAP17, RICH-1) as additional autoimmune target in ARHGAP26-IgG/anti-Ca autoantibody-associated autoimmune encephalitis. J Neurology 2023 Mar;270(3):1776-1780.
• Jarius S, Bräuninger S, Chung HY, Geis C, Haas J, Komorowski L, Wildemann B, Roth C. Inositol 1,4,5-trisphosphate receptor type 1 autoantibody (ITPR1-IgG/anti-Sj)-associated autoimmune cerebellar ataxia, encephalitis and peripheral neuropathy: review of the literature. J Neuroinflammation. 2022 Jul 30;19(1):196. J Neuroinflammation. 2022 Jul 30;19(1):196.
• Jarius S, Komorowski L, Regula JU, Haas J, Brakopp S, Wildemann B. Rho GTPase-activating protein 10 (ARHGAP10/GRAF2) is a novel autoantibody target in patients with autoimmune encephalitis. J Neurol. 2022 Oct;269(10):5420-5430.
• Otto C, Radbruch H, Wilken D, Lietzow T, Steinhagen K, Grage-Griebenow E, von Brünneck AC, Jarius S, Hofmann J, Pache F, Ruprecht K. Frequent intrathecal production of antibodies to the viral capsid antigen of Epstein-Barr virus in patients with central nervous system post-transplant lymphoproliferative disorder. J Neuroimmunol 2022 Aug; 369:577902. 
• Grüter T, Möllers FE, Tietz A, Dargvainiene J, Melzer N, Heidbreder A, Strippel C, Kraft A, Höftberger R, Schöberl F, Thaler FS, Wickel J, Chung HY, Seifert F, Tschernatsch M, Nagel M, Lewerenz J, Jarius S, Wildemann BC, de Azevedo L, Heidenreich F, Heusgen R, Hofstadt-van Oy U, Linsa A, Maaß JJ, Menge T, Ringelstein M, Pedrosa DJ, Schill J, Seifert-Held T, Seitz C, Tonner S, Urbanek C, Zittel S, Markewitz R, Korporal-Kuhnke M, Schmitter T, Finke C, Brüggemann N, Bien CI, Kleiter I, Gold R, Wandinger KP, Kuhlenbäumer G, Leypoldt F, Ayzenberg I; German Network for Research on Autoimmune Encephalitis (GENERATE). Clinical, serological and genetic predictors of response to immunotherapy in anti-IgLON5 disease. Brain. 2022 Mar 8:awac090; in press (doi: 10.1093/brain/awac090).
• Kaulen LD, Doubrovinskaia S, Mooshage C, Jordan B, Purrucker J, Haubner C, Seliger C, Lorenz HM, Nagel S, Wildemann B, Bendszus M, Wick W, Schönenberger S. Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series. Eur J Neurol. 2021 Oct 19. doi: 10.1111/ene.15147. Online ahead of print.
• Hadjivassiliou M, Graus F, Honnorat J, Jarius S, Titulaer M, Manto M, Hoggard N, Sarrigiannis P, Mitoma H. Diagnostic criteria for primary autoimmune cerebellar ataxia-Guidelines from an international task force on immune-mediated cerebellar ataxias. Cerebellum. 2020 Aug;19(4):605-610.
• Grüter T, Ott A, Meyer W, Jarius S, Kinner M, Motte J, Pitarokoili K, Gold R, Komorowski L, Ayzenberg I. Effects of IVIg treatment on autoantibody testing in neurological patients: marked reduction in sensitivity but reliable specificity. J Neurol. 2020 Mar;267(3):715-720.
• Gross CC, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher AR, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud DA, Loussouarn D, Parratt J, Barnett M, Buckland ME, Hardy TA, Reddel SW, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth SG, Martin-Blondel G, Wiendl H, Liblau R. CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome. Nat Commun. 2019 Dec 18;10(1):5779.
• Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger KP, Leypoldt F; German Network for Research on Autoimmune Encephalitis (GENERATE). Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis. Ann Neurol. 2018 Apr;83(4):863-869. 
• Höltje M, Mertens R, Schou MB, Saether SG, Kochova E, Jarius S, Prüss H, Komorowski L, Probst C, Paul F, Bellmann-Strobl J, Gitler D, Benfenati F, Piepgras J, Ahnert-Hilger G, Ruprecht K. Synapsin-antibodies in psychiatric and neurological disorders: prevalence and clinical findings. Brain, Behaviour, and Immunity 2017; epub ahead of print (doi: 10.1016/j.bbi.2017.07.011).
• Wallwitz U, Brock S, Schunck A, Wildemann B, Jarius S, Hoffmann F. From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum. J Neuroimmunol 2017 Aug 15;309:77-81.
• Lewerenz J, Jarius S, Wildemann B, Wandinger KP, Leypoldt F. [Autoantibody-associated autoimmune encephalitis and cerebellitis: Clinical presentation, diagnostic work-up and treatment]. Nervenarzt 2016 Dec;87(12):1293-1299.
• Jarius S, Ringelstein M, Haas J, Serysheva II, Komorowski L, Fechner K, Wandinger KP, Albrecht P, Hefter H, Moser A, Neuen-Jacob E, Hartung HP, Wildemann B, Aktas O. Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy. J Neuroinflammation 2016; 13:278.
• Kleffner I, Dörr J, Ringelstein M, Groß C, Böckenfeld Y, Schwindt W, Sundermann B, Lohmann H, Wersching H, Promesberger J, von Königsmarck N, Alex A, Guthoff R, Frijns CJM, Kappelle JL, Jarius S, Wildemann B, Aktas O, Paul F, Wiendl H, Duning H; for the European Susac Consortium (EuSaC). Diagnostic criteria for Susac Syndrome. JNNP 2016 Dec;87(12):1287-1295.
• Stich O, Perera S, Berger B, Jarius S, Wildemann B, Baumgartner A, Rauer S. Prevalence of neurofascin-155 antibodies in patients with multiple sclerosis. J Neurol Sci 2016 May 15;364:29-32.
• Jarius S, Metz I, König F, Ruprecht K, Reindl M, Paul F, Brück W, Wildemann B. Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in ‘pattern II multiple sclerosis’ and brain biopsy findings in a MOG-IgG-positive case. Mult Scler 2016 Oct;22(12):1541-1549.
• Baron R, Ferriero D, Frisoni G, Bettegowda C, Gokaslan Z, Kessler J, Vezzani A, Waxman S, Weller M, Jarius S, Wildemann B. Neurology-the next 10 years. Nature Rev Neurol 2015; Nov;11(11):658-64. Epub 2015 Oct 27.
• Jarius S, Wildemann B. ‘Medusa head ataxia’: The expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1, anti-CARP VIII. J Neuroinflammation 2015; 12:166. FREE PDF
• Jarius S, Wildemann B. ‘Medusa head ataxia’: The expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26, anti-VGCC. J Neuroinflammation 2015; 12:167. FREE PDF
• Jarius S, Wildemann B. ‘Medusa head ataxia’: The expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, Anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook. J Neuroinflammation 2015; 12:168. FREE PDF
• Jarius S, Wildemann B, Stöcker W, Moser A, Wandinger KP. Psychotic syndrome associated with antibodies to ARHGAP26 (anti-Ca) and voltage-gated potassium channels. J Neuroimmunol 2015 Sep 8; 286:79-82. Epub 2015 Jul 22.
• Piepgras J, Hoeltje M, Michel K, Li Q, Otto C, Drenckhahn C, Probst C, Schemann M, Jarius S, Stöcker W, Balint B, Meinck HM, Buchert R, Dalmau JO, Ahnert-Hilger G, Ruprecht K. Anti-DPPX encephalitis: pathogenic effects of antibodies on gut and brain neurons. Neurology 2015 Sep 8;85(10):890-7. Epub 2015 Aug 19.
• Ringelstein M, Albrecht P, Kleffner I, Bühn B, Harmel J, Müller AK, Finis D, Guthoff R, Bergholz R, Duning T, Krämer M, Paul F, Brandt F, Oberwahrenbrock T, Mikolajczak J, Wildemann B, Jarius S, Hartung HP, Aktas O, Dörr J. Retinal pathology in Susac syndrome detected by spectral-domain optical coherence tomography. Neurology 2015 Aug 18;85(7):610-8. Epub 2015 Jul 22.
• Probst C, Komorowski L, de Graaff E, van Coevorden-Hameete M, Rogemond V, Honnorat J, Sabeter L, Graus F, Jarius S, Voltz R, Wildemann B, Franciotta D, Blöcker I, Schlumberger W, Stöcker W, Sillevis Smitt PAE. Standardized test for anti-Tr/DNER in patients with paraneoplastic cerebellar degeneration. Neurology: Neuroimmunology & Neuroinflammation 2015 Feb 26;2(2):e68.
• Jarius S, Scharf M, Begemann N, Stöcker W, Probst C, Serysheva II, Nagel S, Graus F, Psimaras D, Wildemann B*, Komorowski L*. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. J Neuroinflammation 2014; 11:206.
• Stoeck K, Carstens PO, Jarius S, Raddatz D, Stöcker W, Wildemann B, Schmidt J. Prednisolone and azathioprine are effective in DPPX antibody-positive autoimmune encephalitis. Neurology: Neuroimmunology & Neuroinflammation. 2015 Jun; 2(3): e86. Epub 2015 Mar 12.
• Fidzinski P, Jarius S, Gaebler C, Boegner F, Nohr R, Ruprecht K. Faciobrachial dystonic seizures and antibodies to Lgi1 in a 92-year-old patient: A case report. J Neurol Sci 2014 Oct 22;347(1-2):404-405. Epub 2014 Oct 22.
• Jarius S, Kleffner I, Dörr JM, Sastre-Garriga J, Illes Z, Eggenberger E, Chalk C, Ringelstein M, Aktas O, Montalban X, Fechner K, Stöcker W, Ringelstein EB, Paul F, Wildemann B. Clinical, paraclinical and serological findings in Susac syndrome: an international multi-centre study. J Neuroinflammation 2014 Mar 8; 11:46.
• Balint B, Jarius S, Nagel S, Haberkorn U, Probst C, Blöcker IM, Bahtz R, Komorowski L, Stöcker W, Kastrup A, Kuthe M, Meinck HM. Progressive encephalomyelitis with rigidity and myoclonus: A new variant with DPPX antibodies.Neurology 2014 Apr 29;82(17):1521-8. Epub 2014 Apr 2.
• Doss S, Nümann A, Ziegler A, Siebert E, Borowski K, Stöcker W, Prüss H, Wildemann B, Endres M, Jarius S. Anti-Ca/anti-ARHGAP26 antibodies associated with cerebellar atrophy and cognitive decline. J Neuroimmunol 2014 Feb 15;267(1-2):102-4. Epub 2013 Nov 6.
• Dörr J, Krautwald S, Wildemann B, Jarius S, Ringelstein M, Duning T, Aktas O, Ringelstein EB, Paul F, Kleffner I. Characteristics of Susac syndrome: a review of all reported cases. Nature Rev Neurol 2013 Jun;9(6):307-16.
• Mundiyanapurath S, Jarius S, Probst C, Stöcker W, Wildemann B, Bösel J. GABA-B-receptor antibodies in paraneoplastic brainstem encephalitis. J Neuroimmunol 2013 Jun 15;259(1-2):88-91. Epub 2013 Apr 28.
• Wildemann B, Bien CG. [Immune-mediated encephalomyelitis]. Nervenarzt. 2013 Apr;84(4):435.
• Balint B, Regula JU, Jarius S, Wildemann B. Caspr2-antibodies in limbic encephalitis with cerebellar ataxia, dyskinesias and myoclonus. J Neurol Sci 2013 Apr 15;327(1-2):73-4. Epub 2013 Mar 5.
• Jarius S, Steinmeyer F, Knobel A, Streitberger K, Hotter B, Horn S, Heuer H, Schreiber SJ, Wilhelm T, Trefzer U, Wildemann B, Ruprecht K. GABAB receptor antibodies in paraneoplastic cerebellar ataxia. J Neuroimmunol 2013 Mar 15;256(1-2):94-6. Epub 2013 Jan 14.
• Jarius S, Martínez-García P, Hernandez AL, Brase JC, Borowski K, Regula JU, Meinck HM, Stöcker W, Wildemann B, Wandinger KP. Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia. J Neuroinflammation 2013 Jan 15;10:7.
• Wildemann B, Jarius S. The expanding range of autoimmune disorders of the nervous system. Lancet Neurol 2013 Jan;12(1):22-4.
• Kraus PD, Wolff D, Grauer O, Angstwurm K, Jarius S, Wandinger KP, Holler E, Schulte-Mattler W, Kleiter I. Muscle Cramps and Neuropathies in Patients with Allogeneic Hematopoietic Stem Cell Transplantation and Graft-versus-Host Disease. PLoS ONE 2012; 7(9): e44922. Epub 2012 Sep 17.
• Harrer A, Tumani H, Niendorf S, Lauda F, Geis C, Weishaupt A, Kleinschnitz C, Rauer S, Kuhle J, Stangel M, Weber F, Uhr M, Linnebank M, Wildemann B, Jarius S, Guger M, Ayzenberg I, Chan A, Zettl U, Wiendl H, Pilz G, Hitzl W, Weber JR, Kraus J. Cerebrospinal fluid parameters of B cell-related activity in patients with active disease during natalizumab therapy. Mult Scler 2013 Aug;19(9):1209-1212. Epub 2012 Oct 23.
• Jarius S, Eichhorn P, Wildemann B, Wick M. Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands. Fluids and barrieres of the CNS 2012; 9:14. Epub 2012 July 31.
• Elliott C, Lindner M, Arthur A, Brennan K, Jarius S, Hussey J, Chan A, Stroet A, Tomas Olsson, Willison H, Barnett SC, Meinl E, Linington C. Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain 2012 Jun;135(Pt 6):1819-33. Epub 2012 May 4.
• Wuerfel J, Sinnecker T, Ringelstein EB, Jarius S, Schwindt W, Niendorf T, Paul F, Kleffner I, Dörr J. Lesion morphology at 7 Tesla MRI differentiates Susac syndrome from multiple sclerosis. Mult Scler 2012 Nov;18(11):1592-9. Epub 2012 Jun 18.
• Jarius S, Wandinger KP, Borowski K, Stoecker W, Wildemann B. Antibodies to CV2/CRMP5 in neuromyelitis optica-like disease: Case report and review of the literature. Clin Neurol Neurosurg 2012 May;114(4):331-5. Epub 2011 Dec 3.Haas J, Bekeredjian-Ding I, Milkova M, Balint B, Schwarz A, Korporal M, Jarius S, Fritz B, Lorenz HM,
• Stich O, Klages E, Bischler P, Jarius S, Rasiah C, Voltz R, Rauer S. SOX1 antibodies in sera from patients with paraneoplastic neurological syndromes. Acta Neurol Scand 2012 May;125(5):326-31. Epub 2011 Jul 14.
• Dörr J, Jarius S, Wildemann B, Ringelstein EB, Schwindt W, Deppe M, Wandinger KP, Promesberger J, Paul F, Kleffner I. [Susac syndrome : An interdisciplinary challenge.] Nervenarzt 2011 Oct;82(10):1250-63.
• Piccolo G, Tavazzi E, Jarius S, Alfonsi E, Cavagna L, Piccolo L, Zardini E, Voltz R, Franciotta D. Anti-Ma2/Ta antibodies in a woman with primary lateral sclerosis-like phenotype and Sjögren syndrome. Neurol Sci 2011 Oct;32(5):915-7. Epub 2011 Mar 3.
• Benedetti L, Zardini E, Briani C, Beronio A, Gastaldi S, Jarius S, Mancardi GL, Schenone A, Franciotta D. B-cell-activating factor in rituximab-treated patients with anti-MAG polyneuropathy. J Neurol Neurosurg Psychiatr 2010;Nov;82(11):1291-4. Epub 2010 Dec 16.
• Jarius S, Stich O, Speck J, Rasiah Ch, Wildemann B, Meinck HM, Rauer S. Qualitative and quantitative evidence of anti-glutamic acid decarboxylase-specific intrathecal antibody synthesis in patients with stiff person syndrome. J Neuroimmunol. 2010 Dec 15;229(1-2):219-24. Epub 2010 Sep 1.
• Franciotta D, Di Stefano AL, Jarius S, Zardini E, Tavazzi E, Ballerini C, Marchioni E, Bergamaschi R, Ceroni M. Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases. J Neuroimmunol. 2011 Jan;230(1-2):160-3. Epub 2010 Nov 24.
• Jarius S, Wandinger KP, Horn S, Heuer H, Wildemann B. A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization. J Neuroinflammation 2010 Mar 12;7:21.
• Wandinger KP, Probst C, Komorowski L, Saschenbrecker S, Rosemann A, Mothes T, Zillikens D, Dalmau J, Jarius S, Schlumberger W, Stöcker W. Novel recombinant antigenic targets for the determination of (auto)antibodies in autoimmune dermatoses, neurological disorders and gastrointestinal diseases. In: K. Conrad, E.K.L. Chan, M.J. Fritzler, R.L. Humbel, P. von Landenberg, Y. Shoenfeld (Eds.) From Pathogenesis to Therapy of Autoimmune Diseases, Pabst, Lengerich, Berlin, Bremen, Miami, Riga, Viernheim, Wien, Zagreb 2009, p. 179-190.
• Jarius S, Neumayer B, Wandinger KP, Hartmann M, Wildemann B. Anti-endothelial serum antibodies in a patient with Susac's syndrome. J Neurol Sci 2009 Oct 15;285(1-2):259-61. Epub 2009 Jul 29.
• Jarius S, Arnold S, Linke R, Noachtar S, Schlemmer M, Issels R, Voltz R. Long term survival in anti-Hu associated adult neuroblastoma. J Neurol Sci 2009 Sep 15;284(1-2):205-8. Epub 2009 May 13.
• Stich O, Jarius S, Rasiah C, Voltz R, Rauer S. Recombinant immunoblot for assessment of intrathecally synthesised paraneoplastic antineuronal antibodies in cerebrospinal fluid from patients with paraneoplastic neurological syndromes. Clin Chem Lab Med. 2008;46(12):1793-5.
• Jarius S, Eichhorn P, Jacobi C, Wildemann B, Wick M, Voltz R. The intrathecal, polyspecific antiviral immune response: Specific for MS or a general marker of CNS autoimmunity? J Neurol Sci 2009 May 15;280(1-2):98-100. Epub 2008 Nov 28.
• Franciotta D, Columba-Cabezas S, Andreoni L, Ravaglia S, Jarius S, Romagnolo S, Tavazzi E, Bergamaschi R, Zardini E, Aloisi F, Marchioni E. Oligoclonal IgG band patterns in inflammatory demyelinating human and mouse diseases. J Neuroimmunol. 2008 Aug 30;200(1-2):125-8. Epub 2008 Jul 7.
• Jarius S, Hoffmann LA, Stich O, Clover L, Rauer S, Vincent A, Voltz R. Relative frequency of VGKC and 'classical' paraneoplastic antibodies in patients with limbic encephalitis. J Neurol 2008 Jul;255(7):1100-1. Epub 2008 Jun 27.
• Hoffmann LA, Jarius S, Pellkofer HL, Schueller M, Krumbholz M, Koenig F, Johannis W, la Fougere C, Newman T, Vincent A, Voltz R. Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases. J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):767-73. Epub 2008 Jan 25.
• Jarius S, Stich O, Rasiah C, Voltz R, Rauer S. Qualitative evidence of Ri specific IgG-synthesis in the cerebrospinal fluid from patients with paraneoplastic neurological syndromes. J Neurol Sci 2008 May 15;268(1-2):65-8. Epub 2007 Dec 21.
• Jarius S, Hoffmann L, Clover L, Vincent A, Voltz R. CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis. J Neurol Sci 2008 May 15;268(1-2):74-7. Epub 2008 Feb 20.
• Poepel A, Jarius S, Heukamp LC, Urbach H, Elger CE, Bien CG, Voltz R. Neurological course of long-term surviving patients with SCLC and anti-Hu syndrome. J Neurol Sci 2007 Dec 15;263(1-2):145-8. Epub 2007 Aug 15.
• Jarius S, Eichhorn P, Albert MH, Wagenpfeil S, Wick M, Belohradsky BH, Hohlfeld R, Jenne DE, Voltz R. Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNFalpha-dependent and Fc-receptor-independent way. Blood 2007 May 15;109(10):4376-82. Epub 2007 Jan 30.
• Stich O, Jarius S, Kleer B, Rasiah C, Voltz R, Rauer S. Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes. J Neuroimmunol 2007 Feb;183(1-2):220-4. Epub 2007 Jan 16.
• Fauser S, Talazko J, Wagner K, Ziyeh S, Jarius S, Vincent A, Schulze-Bonhage A. FDG-PET and MRI in potassium channel antibody-associated non-paraneoplastic limbic encephalitis: correlation with clinical course and neuropsychology. Acta Neurol Scand 2005 May;111(5):338-43.
• Hensel IV, Éliás S, Steinhauer M, Stoll B, Benfatto S, Merkt W, Krienke S, Lorenz HM, Haas J, Wildemann B, Resnik-Docampo M. SLE serum induces altered goblet cell differentiation and leakiness in human intestinal organoids. EMBO Mol Med. 2024 Mar;16(3):547-574.