Prof. Dr. med. Rawa Arif

Leiter der AG Multimodale Therapie des Marfan-Syndroms

Habilitation an der Ruprecht-Karls-Universität Heidelberg unter der Leitung von Prof. Dr. med. Matthias Karck, „Einfluss endothelialer Dysfunktion und struktureller Gefäßwandveränderungen auf das Outcome herzchirurgischer Patienten“

Oberarzt an der Klinik für Herzchirurgie, Universitätsklinikum Heidelberg

Leiter der AG Kardiovaskuläre Gentherapie

Facharzt für Herzchirurgie

Promotion an der Ruprecht-Karls-Universität Heidelberg, „Endotheliale Dysfunktion durch oxidativen Stress – neue therapeutische Ansätze durch Vardenafil und PARP-Inhibition (INO-1001)“ (magna cum laude)

Assistenzarzt an der Klinik für Herzchirurgie, Universitätsklinikum Heidelberg

Praktisches Jahr an der Universitätsklinik Heidelberg und dem Inselspital Bern, Schweiz (Abteilung für Herzchirurgie, Prof. Th. Carrel)

Studium der Humanmedizin an der Universität Heidelberg, Erasmusaufenthalt Universität Wien

Mitglied des Promotionsausschusses der Medizinischen Fakultät der Universität Heidelberg

Projektgruppe Neubau Herzzentrum Heidelberg

Lehrkoordinator der Klinik für Herzchirurgie

Deutsche Forschungsgemeinschaft (DFG): Projektnummer 508473803: Titel "Minimal-invasive Therapie des Marfan-Syndroms: lokale AAV-vermittelte Hemmung von thorakalen Aortenaneurysmen und Aortendissektionen."

Dietmar Hopp Stiftung: Gentherapie der Transplantatvaskulopathie – in Kooperation mit der Herz-Kreislaufphysiologie und Kardiologie, Eingeworbener Förderbetrag: 382.432 €

B. Braun Stiftung: Inhibition der aortalen Elastolyse durch Decoy Oligodesoxynukleotide-vermittelte Hemmung der Transkription von Matrix-Metalloproteinasenin der Fribrillin-1 defizienten Maus mgR/mgR (Marfan-Modell) Eingeworbener Förderbetrag: 21.000 €

Gefäßchirurgischer Forschungspreis der deutschen Gesellschaft für Herz-, Thorax- und Gefäßchirurgie (DGTHG) für die experimentelle Arbeit zum Thema Gentherapie des Marfan-Syndroms

Franz J. Köhler Preis für experimentellen Arbeiten zum Thema Gentherapie der Transplantatvaskulopathie

Krey R, Jakob M, Karck M, Arif R, Farag M (2024)
Male-female differences following concomitant coronary artery bypass grafting and aortic valve replacement surgery.
ESC Heart Fail. 2024 Oct;11(5):2913-2923. doi: 10.1002/ehf2.14847. Epub 2024 May 26. PMID: 38797557 Free PMC article.
 

Böning A, Kretzer JA, Arif R, Etz CD, Pöling J, Rylski B, Czerny M, Brickwedel J, Peterss S, Holubec T, Jawny P, Krueger T, Feißt M; GERAADA Study Group (2024)
Risk factors for long-term mortality after acute aortic dissection-results of the German registry for acute aortic dissection type a long-term follow-up.
Eur J Cardiothorac Surg. 2024 Mar 29;65(4):ezae116. doi: 10.1093/ejcts/ezae116. PMID: 38530802 

 

Paasche A, Wiedmann F, Kraft M, Seibertz F, Herlt V, Blochberger PL, Jávorszky N, Beck M, Weirauch L, Seeger T, Blank A, Haefeli WE, Arif R, Meyer AL, Warnecke G, Karck M, Voigt N, Frey N, Schmidt C (2024)

Acute antiarrhythmic effects of SGLT2 inhibitors-dapagliflozin lowers the excitability of atrial cardiomyocytes.

Basic Res Cardiol. 2024 Feb;119(1):93-112. doi: 10.1007/s00395-023-01022-0. Epub 2024 Jan 3. PMID: 38170280 Free PMC article.

Sommer W, Arif R, Warnecke G (2024)
Reply from authors: Shouldn't we start gathering evidence for improved hemodynamic support in patients with postcardiotomy cardiogenic shock?
JTCVS Open. 2024 Jan 26;18:90. doi: 10.1016/j.xjon.2024.01.011. eCollection 2024 Apr. PMID: 38690405 Free PMC article. No abstract available. 

Al-Maisary S, Romano G, Karck M, De Simone R, Kremer J, Arif R (2023)

Octogenarian patients and laser-assisted lead extraction: Should we put a limit?

PLoS One. 2023 Oct 20;18(10):e0284802. doi: 10.1371/journal.pone.0284802. eCollection 2023. PMID: 37862289 Free PMC article.

Turra J, Riesterer D, Eisner C, Wenzel F, Möbius A, Karck M, Arif R, Lichtenstern C, Fischer D (2023)

Prospective clinical study testing the efficacy and safety of a new formula to increase the precision of oxygen therapy in the initiation phase of cardiopulmonary bypass.

Perfusion. 2023 Sep;38(6):1203-1212. doi: 10.1177/02676591221100743. Epub 2022 May 24. PMID: 35608437 Free PMC article. 

Farag M, Büsch C, Rylski B, Pöling J, Dohle DS, Sarvanakis K, Hagl C, Krüger T, Detter C, Holubec T, Borger MA, Böning A, Karck M, Arif R; German Registry for Acute Aortic Dissection Type A Working Group of the German Society of Thoracic, Cardiac and Vascular Surgery. (2023)

Early outcomes of patients with Marfan syndrome and acute aortic type A dissection.

J Thorac Cardiovasc Surg. 2023 Jul;166(1):25-34.e8. doi: 10.1016/j.jtcvs.2021.07.024. Epub 2021 Jul 21. PMID: 34446289

Merkle-Storms J, Gaisendrees C, Feisst M, Rylski B, Dohle DS, Hagl C, Lescan M, Brickwede J, Poeling J, Holubec T, Etz CD, Jawny P, Noack T, Arif R, Wahlers T, Boening A, Luehr M (2023)

The correlation of age and extension length in DeBakey type I aortic dissection: are older patients over 70 years at a lower risk?

Eur J Cardiothorac Surg. 2023 Jun 1;63(6):ezad175. doi: 10.1093/ejcts/ezad175. PMID: 37104742 

Krey R, Sommer W, Meyer A, Rivinius R, Schlegel P, Frey N, Karck M, Warnecke G, Arif R (2023)

Influence of Tricuspid Regurgitation After Heart Transplantation: A Single-center Experience.

Transplant Direct. 2023 Feb 17;9(3):e1452. doi: 10.1097/TXD.0000000000001452. eCollection 2023 Mar. PMID: 36845859 Free PMC article.

Dietrich M, Antonovici A, Hölle T, Nusshag C, Kapp AC, Studier-Fischer A, Arif R, Nickel F, Weigand MA, Frey N, Lichtenstern C, Leuschner F, Fischer D (2023)

Microcirculatory tissue oxygenation correlates with kidney function after transcatheter aortic valve implantation-Results from a prospective observational study.

Front Cardiovasc Med. 2023 Feb 14;10:1108256. doi: 10.3389/fcvm.2023.1108256. eCollection 2023. PMID: 36865886 Free PMC article.

Meinert ÉFRC, Arif R, Karck M (2022)

Redo aortic arch replacement through a second transcostal approach for closure of type 1A endoleak after endovascular treatment of type B aortic dissection in Marfan syndrome.

Eur J Cardiothorac Surg. 2022 Dec 2;63(1):ezac574. doi: 10.1093/ejcts/ezac574. PMID: 36534925

Zaradzki M, Mohr F, Lont S, Soethoff J, Remes A, Arif R, Müller OJ, Karck M, Hecker M, Wagner AH (2022)

Short-term rapamycin treatment increases life span and attenuates aortic aneurysm in a murine model of Marfan-Syndrome.

Biochem Pharmacol. 2022 Nov;205:115280. doi: 10.1016/j.bcp.2022.115280. Epub 2022 Oct 2. PMID: 36198355

Arif R, Warninck A, Farag M, Sommer W, Leuschner F, Frey N, Karck M, Warnecke G, Geis NA (2022)

Long-Term Patency of Venous Conduits Targeting the Right Coronary Artery System-Single Is Superior to Sequential bypass Grafting.

J Cardiovasc Dev Dis. 2022 Aug 26;9(9):285. doi: 10.3390/jcdd9090285. PMID: 36135430

Mayer D, Altvater M, Schenz J, Arif R, Karck M, Leuschner F, Weigand MA, Uhle F, Lichtenstern C (2022)

Monocyte Metabolism and Function in Patients Undergoing Cardiac Surgery.

Front Cardiovasc Med. 2022 Jul 13;9:853967. doi: 10.3389/fcvm.2022.853967. eCollection 2022. PMID: 35935635 Free PMC article.

Kallenbach K, Remes A, Müller OJ, Arif R, Zaradzki M, Wagner AH (2022)

Translational Medicine: Towards Gene Therapy of Marfan Syndrome.

J Clin Med. 2022 Jul 6;11(14):3934. doi: 10.3390/jcm11143934. PMID: 35887698 Free PMC article. Review.

Wiedmann F, Beyersdorf C, Zhou XB, Kraft M, Paasche A, Jávorszky N, Rinné S, Sutanto H, Büscher A, Foerster KI, Blank A, El-Battrawy I, Li X, Lang S, Tochtermann U, Kremer J, Arif R, Karck M, Decher N, van Loon G, Akin I, Borggrefe M, Kallenberger S, Heijman J, Haefeli WE, Katus HA, Schmidt C (2022)

Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy.

Cardiovasc Res. 2022 Jun 22;118(7):1728-1741. doi: 10.1093/cvr/cvab177. PMID: 34028533

Turra J, Riesterer D, Eisner C, Wenzel F, Möbius A, Karck M, Arif R, Lichtenstern C, Fischer D (2022)

Prospective clinical study testing the efficacy and safety of a new formula to increase the precision of oxygen therapy in the initiation phase of cardiopulmonary bypass.

Perfusion. 2022 May 24:2676591221100743. doi: 10.1177/02676591221100743. Online ahead of print. PMID: 35608437

Kallenbach K, Büsch C, Rylski B, Dohle DS, Krüger T, Holubec T, Brickwedel J, Pöling J, Noack T, Hagl C, Jawny P, Böning A, Chalabi K, Karck M, Arif R (2022)

Treatment of the aortic root in acute aortic dissection type A: insights from the German Registry for Acute Aortic Dissection Type A.

Eur J Cardiothorac Surg. 2022 May 2:ezac261. doi: 10.1093/ejcts/ezac261. Online ahead of print. PMID: 35511255

Kallenbach K, Büsch C, Rylski B, Dohle DS, Krüger T, Holubec T, Brickwedel J, Pöling J, Noack T, Hagl C, Jawny P, Böning A, Chalabi K, Karck M, Arif R (2022)

Treatment of the Aortic Root in Acute Aortic Dissection Type A: Insights from the German Registry for Acute Aortic Dissection Type A (GERAADA) Registry.

Eur J Cardiothorac Surg. 2022 Apr 20:ezac261. doi: 10.1093/ejcts/ezac261. Online ahead of print. PMID: 35441677

Wiedmann F, Kraft M, Kallenberger S, Büscher A, Paasche A, Blochberger PL, Seeger T, Jávorszky N, Warnecke G, Arif R, Kremer J, Karck M, Frey N, Schmidt C (2022)

MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation.

J Am Heart Assoc. 2022 Apr 5;11(7):e023472. doi: 10.1161/JAHA.121.023472. Epub 2022 Mar 18. PMID: 35301863

Remes A, Arif R, Franz M, Jungmann A, Zaradzki M, Puehler T, Md MBH, Frey N, Karck M, Kallenbach K, Hecker M, Müller OJ, Wagner AH (2021)

AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of marfan syndrome.

Cardiovasc Res. 2021 Nov 1;117(12):2459-2473. doi: 10.1093/cvr/cvab012.

Al-Maisary S, Farag M, Te Gussinklo WH, Kremer J, Pleger ST, Leuschner F, Karck M, Szabo G, Arif R (2021)

Are Sutureless and Rapid-Deployment Aortic Valves a Serious Alternative to TA-TAVI? A Matched-Pairs Analysis.

J Clin Med. 2021 Jul 12;10(14):3072. doi: 10.3390/jcm10143072. PMID: 34300238

Remes A, Basha DI, Puehler T, Borowski C, Hille S, Kummer L, Wagner AH, Hecker M, Soethoff J, Lutter G, Frank D, Arif R, Frey N, Zaradzki M, Müller OJ (2021)

Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue.

Mol Ther Methods Clin Dev. 2021 Feb 24;21:83-93. doi: 10.1016/j.omtm.2021.02.017. eCollection 2021 Jun 11. PMID: 33768132

Kummer L, Zaradzki M, Vijayan V, Arif R, Weigand MA, Immenschuh S, Wagner AH, Larmann J (2020)

Vascular Signaling in Allogenic Solid Organ Transplantation - The Role of Endothelial Cells.

Front Physiol. 2020 May 8;11:443. doi: 10.3389/fphys.2020.00443. eCollection 2020. PMID: 32457653

Remes A, Franz M, Zaradzki M, Borowski C, Frey N, Karck M, Kallenbach K, Müller OJ, Wagner AH, Arif R (2020)

AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice.

J Heart Lung Transplant. 2020 Apr;39(4):389-398. doi: 10.1016/j.healun.2020.01.1338. Epub 2020 Jan 30.

Gi WT, Sedaghat-Hamedani F, Shirvani Samani O, Kayvanpour E, Herpel E, Arif R, Riffel J, Mereles D, Katus HA, Meder B (2020)

Cardiac Myxoma in a Patient With Hypertrophic Cardiomyopathy.

JACC Case Rep. 2020 Feb 12;2(3):378-383. doi: 10.1016/j.jaccas.2019.11.072. eCollection 2020 Mar. PMID: 34317246 Free PMC article.

Dib B, Seppelt PC, Arif R, Weymann A, Veres G, Schmack B, Beller CJ, Ruhparwar A, Karck M, Kallenbach K (2019)

Extensive aortic surgery in acute aortic dissection type A on outcome - insights from 25 years single center experience.

J Cardiothorac Surg. 2019 Nov 6;14(1):187. doi: 10.1186/s13019-019-1007-7.

Remes A, Franz M, Mohr F, Weber A, Rapti K, Jungmann A, Karck M, Hecker M, Kallenbach K, Müller OJ, Arif R, Wagner AH (2019)

AAV-Mediated Expression of AP-1-Neutralizing RNA Decoy Oligonucleotides Attenuates Transplant Vasculopathy in Mouse Aortic Allografts.

Mol Ther Methods Clin Dev. 2019 Oct 2;15:246-256. doi: 10.1016/j.omtm.2019.09.009. eCollection 2019 Dec 13.

Farag M, Arif R, Raake P, Kreusser M, Karck M, Ruhparwar A, Schmack B (2019)

Cardiac surgery in the heart transplant recipient: Outcome analysis and long-term results.

Clin Transplant. 2019 Oct;33(10):e13709. doi: 10.1111/ctr.13709. Epub 2019 Sep 30.

Arif R, Franz M, Remes A, Zaradzki M, Hecker M, Karck M, Müller OJ, Kallenbach K, Wagner AH (2019)

Reduction of Transplant Vasculopathy by Intraoperative Nucleic Acid-based Therapy in a Mouse Aortic Allograft Model.

Thorac Cardiovasc Surg. 2019 Sep;67(6):503-512. doi: 10.1055/s-0038-1673633. Epub 2018 Oct 23.

Kremer J, Farag M, Zaradzki M, Szabó G, Ruhparwar A, Kallenbach K, Karck M, Arif R (2019)

The reimplantation valve-sparing aortic root replacement technique for patients with Marfan syndrome: A single-center experience.

Sci Rep. 2019 Aug 19;9(1):12021. doi: 10.1038/s41598-019-48572-9.

Farag M, Veres G, Szabó G, Ruhparwar A, Karck M, Arif R (2019)

Hyperbilirubinaemia after cardiac surgery: the point of no return.

ESC Heart Fail. 2019 Aug;6(4):694-700. doi: 10.1002/ehf2.12447. Epub 2019 May 16.

Wagner AH, Zaradzki M, Arif R, Remes A, Müller OJ, Kallenbach K (2019)

Marfan syndrome: A therapeutic challenge for long-term care.

Biochem Pharmacol. 2019 Jun;164:53-63. doi: 10.1016/j.bcp.2019.03.034. Epub 2019 Mar 27. Review.

Engelke J, Karmonik C, Rengier F, Partovi S, Popov AF, Osswald A, Arif R, Schmack B, Raake P, Simon AR, Doesch A, Weymann A, Lotz J, Karck M, Ruhparwar A (2018)

Competing Flow Between Partial Circulatory Support and Native Cardiac Output: A Clinical Computational Fluid Dynamics Study.

ASAIO J. 2018 Sep/Oct;64(5):636-642. doi: 10.1097/MAT.0000000000000701.

Arif R, Zaradzki M, Remes A, Seppelt P, Kunze R, Schröder H, Schwill S, Ensminger SM, Robinson PN, Karck M, Müller OJ, Hecker M, Wagner AH, Kallenbach K (2017)

AP-1 Oligodeoxynucleotides Reduce Aortic Elastolysis in a Murine Model of Marfan Syndrome.

Mol Ther Nucleic Acids. 2017 Dec 15;9:69-79. doi: 10.1016/j.omtn.2017.08.014. Epub 2017 Sep 20.

Schmack B, Seppelt P, Weymann A, Alt C, Farag M, Arif R, Doesch AO, Raake PW, Kallenbach K, Mansur A, Popov AF, Karck M, Ruhparwar A (2017)

Extracorporeal life support with left ventricular decompression-improved survival in severe cardiogenic shock: results from a retrospective study.

PeerJ. 2017 Sep 29;5:e3813. doi: 10.7717/peerj.3813. eCollection 2017.

Farag M, Borst T, Sabashnikov A, Zeriouh M, Schmack B, Arif R, Beller CJ, Popov AF, Kallenbach K, Ruhparwar A, Dohmen PM, Szabó G, Karck M, Weymann A (2017)

Surgery for Infective Endocarditis: Outcomes and Predictors of Mortality in 360 Consecutive Patients.

Med Sci Monit. 2017 Jul 25;23:3617-3626.

Weymann A, Farag M, Sabashnikov A, Fatullayev J, Zeriouh M, Schmack B, Arif R, Müller F, Alt C, Raake P, Prakash Patil N, Popov AF, Rüdiger Simon A, Karck M, Ruhparwar A; Heidelberg-Cologne-Harefield Cardiothoracic Transplantation & Mechanical Circulatory Support Outcomes Research Group (2017)

Central Extracorporeal Life Support With Left Ventricular Decompression to Berlin Heart Excor: A Reliable "Bridge to Bridge" Strategy in Crash and Burn Patients.

Artif Organs. 2017 Jun;41(6):519-528. doi: 10.1111/aor.12792. Epub 2016 Nov 8.

Farag M, Nikolic M, Arif R, Schmack B, Sabashnikov A, Zeriouh M, Popov AF, Ruhparwar A, Karck M, Weymann A (2017)

Cardiac Surgery in Patients With Previous Hepatic or Renal Transplantation: A Pair-Matched Study.

Ann Thorac Surg. 2017 May;103(5):1467-1474. doi: 10.1016/j.athoracsur.2016.08.092. Epub 2016 Nov 17.

Farag M, Arif R, Sabashnikov A, Zeriouh M, Popov AF, Ruhparwar A, Schmack B, Dohmen PM, Szabó G, Karck M, Weymann A (2017)

Repair or Replacement for Isolated Tricuspid Valve Pathology? Insights from a Surgical Analysis on Long-Term Survival.

Med Sci Monit. 2017 Feb 25;23:1017-1025.

Farag M, Patil NP, Sabashnikov A, Arif R, Szabó G, Kallenbach K, Ruhparwar A, Karck M, Brenner T, Hofer S, Weymann A (2017)

Comparison of Two Miniaturized Cardiopulmonary Bypass Systems Regarding Inflammatory Response.

Artif Organs. 2017 Feb;41(2):139-145. doi: 10.1111/aor.12750. Epub 2016 Sep 22.

Arif R, Farag M, Zaradzki M, Reissfelder C, Pianka F, Bruckner T, Kremer J, Franz M, Ruhparwar A, Szabo G, Beller CJ, Karck M, Kallenbach K, Weymann A (2016)

Ischemic Colitis after Cardiac Surgery: Can We Foresee the Threat?

PLoS One. 2016 Dec 15;11(12):e0167601. doi: 10.1371/journal.pone.0167601. eCollection 2016.

Kremer J, Farag M, Arif R, Brcic A, Sabashnikov A, Schmack B, Popov AF, Karck M, Dohmen PM, Ruhparwar A, Weymann A (2016)

Total Artificial Heart Implantation After Undifferentiated High-Grade Sarcoma Excision.

Med Sci Monit Basic Res. 2016 Nov 2;22:128-131.

Hirschberg K, Wiedmann F, Zitron E, Fortner P, Riffel JH, Chorianopoulos E, Gdynia G, Mechtersheimer G, Andrassy M, Szabó G, Arif R, Katus HA, Buss SJ (2016)

Incidental finding of a giant intracardiac angioma infiltrating both ventricles in a 35-year-old woman: a case report.

J Med Case Rep. 2016 Apr 12;10:94. doi: 10.1186/s13256-016-0860-4.

Arif R, Farag M, Gertner V, Szabó G, Weymann A, Veres G, Ruhparwar A, Bekeredjian R, Bruckner T, Karck M, Kallenbach K, Beller CJ (2016)

Female Gender and Differences in Outcome after Isolated Coronary Artery Bypass Graft Surgery: Does Age Play a Role?

PLoS One. 2016 Feb 4;11(2):e0145371. doi: 10.1371/journal.pone.0145371. eCollection 2016.

Seppelt PC, Schwill S, Weymann A, Arif R, Weber A, Zaradzki M, Richter K, Ensminger S, Robinson PN, Wagner AH, Karck M, Kallenbach K (2016)

Loss of Endothelial Barrier in Marfan Mice (mgR/mgR) Results in Severe Inflammation after Adenoviral Gene Therapy.

PLoS One. 2016 Feb 3;11(2):e0148012. doi: 10.1371/journal.pone.0148012. eCollection 2016.

Arif R, De Simone R, Karck M, Auch-Schwelk W (2016)

Coronary Stenosis Associated with a Giant Coronary Aneurysm.

J Card Surg. 2016 Feb;31(2):98-9. doi: 10.1111/jocs.12658. Epub 2015 Dec 2. No abstract available.

Arif R, Eichhorn F, Kallenbach K, Seppelt P, Ruhparwar A, Dienemann H, Karck M (2015)

Resection of thoracic malignancies infiltrating cardiac structures with use of cardiopulmonary bypass.

J Cardiothorac Surg. 2015 Jun 25;10:87. doi: 10.1186/s13019-015-0296-8.

Beller CJ, Farag M, Wannaku S, Seppelt P, Arif R, Ruhparwar A, Karck M, Weymann A, Kallenbach K (2015)

Gender-specific differences in outcome of ascending aortic aneurysm surgery.

PLoS One. 2015 Apr 22;10(4):e0124461. doi: 10.1371/journal.pone.0124461. eCollection 2015.

Karmonik C, Partovi S, Rengier F, Meredig H, Farag MB, Müller-Eschner M, Arif R, Popov AF, Kauczor HU, Karck M, Ruhparwar A (2015)

Hemodynamic assessment of partial mechanical circulatory support: data derived from computed tomography angiographic images and computational fluid dynamics.

Cardiovasc Diagn Ther. 2015 Apr;5(2):160-5. doi: 10.3978/j.issn.2223-3652.2015.03.03.

Takahashi H, Arif R, Almashhoor A, Ruhparwar A, Karck M, Kallenbach K (2015)

Long-term results after surgical treatment of postinfarction ventricular septal rupture.

Eur J Cardiothorac Surg. 2015 Apr;47(4):720-4. doi: 10.1093/ejcts/ezu248. Epub 2014 Jul 3.

Takahashi H, Gertner V, Arif R, Kallenbach K, Karck M, Ruhparwar A (2014)

Facilitated aortic valve replacement with complete sternotomy and minimal skin incision using endoscopy: a case of surgical report.

Ann Thorac Cardiovasc Surg. 2014;20 Suppl:709-12. doi: 10.5761/atcs.cr.12.01917. Epub 2013 Mar 26.

Arif R, Ruhparwar A, Kallenbach K, Weymann A, Schmack B, Karck M, Gorenflo M (2014)

Amplatzer™ occlusion device implantation in a patient with biventricular HeartWare®.

Int J Artif Organs. 2014 Jan;37(1):93-5. doi: 10.5301/ijao.5000260. Epub 2014 Jan 30.

Kallenbach K, Kojic D, Oezsoez M, Bruckner T, Sandrio S, Arif R, Beller CJ, Weymann A, Karck M (2013)

Treatment of ascending aortic aneurysms using different surgical techniques: a single-centre experience with 548 patients.

Eur J Cardiothorac Surg. 2013 Aug;44(2):337-45. doi: 10.1093/ejcts/ezs661. Epub 2013 Jan 7.

Takahashi H, Arif R, Kallenbach K, Tochtermann U, Karck M, Ruhparwar A (2013)

Surgical treatment of aortic valve endocarditis with left ventricular-aortic discontinuity.

Ann Thorac Surg. 2013 Jul;96(1):72-6. doi: 10.1016/j.athoracsur.2013.03.060. Epub 2013 May 11.

Radovits T, Arif R, Bömicke T, Korkmaz S, Barnucz E, Karck M, Merkely B, Szabó G (2013)

Vascular dysfunction induced by hypochlorite is improved by the selective phosphodiesterase-5-inhibitor vardenafil.

Eur J Pharmacol. 2013 Jun 15;710(1-3):110-9. doi: 10.1016/j.ejphar.2013.04.012. Epub 2013 Apr 23.

Beller CJ, Schmack B, Seppelt P, Arif R, Bekeredjian R, Krumsdorf U, Katus HA, Karck M, Kallenbach K (2013)

The groin first approach for transcatheter aortic valve implantation: are we pushing the limits for transapical implantation?

Clin Res Cardiol. 2013 Feb;102(2):111-7. doi: 10.1007/s00392-012-0502-9. Epub 2012 Aug 5.

Arif R, Seppelt P, Schwill S, Kojic D, Ghodsizad A, Ruhparwar A, Karck M, Kallenbach K (2012)

Predictive risk factors for patients with cirrhosis undergoing heart surgery.

Ann Thorac Surg. 2012 Dec;94(6):1947-52. doi: 10.1016/j.athoracsur.2012.06.057. Epub 2012 Aug 24.

Loganathan S, Radovits T, Korkmaz S, Hirschberg K, Barnucz E, Weymann A, Bömicke T, Arif R, Karck M, Szabó G (2012)

Enhancement of myocardial and vascular function after phosphodiesterase-5 inhibition in a rat model.

Thorac Cardiovasc Surg. 2012 Jun;60(4):247-54. doi: 10.1055/s-0031-1298059. Epub 2012 Jan 17.

Gertner V, Bordel V, Tochtermann U, Kallenbach K, Verch M, Ungerer M, Piontek P, Arif R, Hasani MR, Takahashi H, Farag M, Ruhparwar A, Karck M, Ghodsizad A, Hasani AR (2010)

Management of biventricular assist device implantation in patients with necrotic pancreatitis.

Heart Surg Forum. 2010 Dec;13(6):E413-4. doi: 10.1532/HSF98.20101067.

Korkmaz S, Radovits T, Barnucz E, Neugebauer P, Arif R, Hirschberg K, Loganathan S, Seidel B, Karck M, Szabó G (2009)

Dose-dependent effects of a selective phosphodiesterase-5-inhibitor on endothelial dysfunction induced by peroxynitrite in rat aorta.

Eur J Pharmacol. 2009 Aug 1;615(1-3):155-62. doi: 10.1016/j.ejphar.2009.05.020. Epub 2009 May 29

Radovits T, Korkmaz S, Loganathan S, Barnucz E, Bömicke T, Arif R, Karck M, Szabó G (2009)

Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H125-33. doi: 10.1152/ajpheart.00165.2009. Epub 2009 May 8.

Radovits T, Bömicke T, Kökény G, Arif R, Loganathan S, Kécsán K, Korkmaz S, Barnucz E, Sandner P, Karck M, Szabó G (2009)

The phosphodiesterase-5 inhibitor vardenafil improves cardiovascular dysfunction in experimental diabetes mellitus.

Br J Pharmacol. 2009 Mar;156(6):909-19. doi: 10.1111/j.1476-5381.2008.00098.x. Epub 2009 Mar 4.

Radovits T, Zotkina J, Lin LN, Bömicke T, Arif R, Gerö D, Horváth EM, Karck M, Szabó C, Szabó G (2007)

Poly(ADP-Ribose) polymerase inhibition improves endothelial dysfunction induced by hypochlorite.

Exp Biol Med (Maywood). 2007 Oct;232(9):1204-12.