apl. Prof. Joachim Füllekrug, PhD
Forschungsgruppenleiter
(AG Prof. Dr. J. Füllekrug)
Wiss. Mitarbeiter
(Klinik für Gastroenterologie, Hepatologie, Infektionskrankheiten, Vergiftungen)
Ärztlicher / Beruflicher Werdegang
- 2015
Honorary University title: apl. Professor
- 2006
Venia legendi for Biochemistry, University of Heidelberg equivalent to Associate Professor
- seit 2004
Principal investigator, Internal Medicine IV, University of Heidelberg
- 1999 – 2003
Research associate, MPI Molecular Cell Biology, Heidelberg/Dresden, Prof. Dr. Kai Simons
- 1996 – 1998
Postdoctoral research fellow at the European Molecular Biology Laboratory Cell Biology Program, Heidelberg, Dr. T. Nilsson
- 1992 – 1995
PhD in Biochemistry, University of Göttingen, Prof. Dr. H. D. Söling
- 1992
Diploma in Chemistry, University of Göttingen
- 1989 – 1990
Academic exchange, University of Kent at Canterbury, England
Selected publications
Exner T, Romero-Brey I, Yifrach E, Rivera-Monroy J, Schrul B, Zouboulis CC, Stremmel W, Honsho M, Bartenschlager R, Zalckvar E, Poppelreuther M, Füllekrug J (2019) An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1. J Cell Sci 132, dx.doi.org/10.1242/jcs.223016
Poppelreuther M, Sander S, Minden F, Dietz MS, Exner T, Du C, Zhang I, Ehehalt F, Knuppel L, Domschke S, Badenhop A, Staudacher S, Ehehalt R, Stremmel W, Thiele C, Heilemann M, Füllekrug J (2018) The metabolic capacity of lipid droplet localized acyl-CoA synthetase 3 is not sufficient to support local triglyceride synthesis independent of the endoplasmic reticulum in A431 cells. Biochim Biophys Acta Mol Cell Biol Lipids 1863, 614, dx.doi.org/10.1016/j.bbalip.2018.03.003
Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trumbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol 13, 91, dx.doi.org/10.1038/nchembio.2239
Küch E, Vellaramkalayil R, Zhang I, Lehnen D, Brügger B, Stremmel W, Ehehalt R, Poppelreuther M, Füllekrug J (2014). Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol. BBA Mol Biol Cell Lipids 1841, 227, doi.org/10.1016/j.bbalip.2013.10.018
Poppelreuther M, Rudolph B, Du C, Grossmann R, Becker M, Thiele C, Ehehalt R, Füllekrug J (2012) The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake. J Lipid Res 53, 888, dx.doi.org/10.1194/jlr.M024562
Weiss KH, Lozoya JC, Tuma S, Gotthardt D, Reichert J, Ehehalt R, Stremmel W, Füllekrug J (2008) Copper-induced translocation of the Wilson disease protein ATP7B independent of Murr1/COMMD1 and Rab7. Am J Pathol 173, 1783, dx.doi.org/10.2353/ajpath.2008.071134
Milger K, Herrmann T, Becker C, Gotthardt D, Zickwolf J, Ehehalt R, Watkins PA, Stremmel W, Füllekrug J (2006) Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci 119, 4678, dx.doi.org/10.1242/jcs.03280
Meder D, Shevchenko A, Simons K, Füllekrug J (2005) Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells. J Cell Biol 168, 303, dx.doi.org/10.1083/jcb.200407072
Schuck S, Manninen A, Honsho M, Füllekrug J, Simons K (2004) Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proc Natl Acad Sci U S A 101, 4912, dx.doi.org/10.1073/pnas.0401285101
Füllekrug J, Suganuma T, Tang BL, Hong W, Storrie B, Nilsson T (1999) Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Mol Biol Cell 10, 1939, dx.doi.org/10.1091/mbc.10.6.1939