The 22nd Dutch-German…

The 22nd Dutch-German Joint Meeting of the Molecular Cardiology Working Groups

March 13th-15th, 2025

Insights into Cutting-Edge Cardiovascular Research and Therapeutics

Theme of the 22nd Dutch-German Joint Meeting (DGJM) in Heidelberg

The 22nd DGJM will focus on innovative approaches in cardiovascular research, with a particular emphasis on the latest breakthroughs in understanding cardiac diseases and the development of innovative, personalized therapies. This year, the meeting will be hosted in the historic city of Heidelberg, providing a stimulating environment for scientists to engage in discussions on the forefront of cardiovascular science.

The meeting will explore a wide range of themes, beginning with cardiac gene regulatory mechanisms and their influence on heart function. The use of cutting-edge in vitro models will be showcased to advance our understanding of cardiovascular development, disease, and therapeutic testing. A key highlight will be the emerging role of mRNA technologies in diagnosing and treating heart diseases. Additionally, we will dive into the complex relationships between cardiac metabolism and heart failure, specifically the differences between HFpEF and HFrEF, and will discuss the important role of inter-organ communication involved in heart failure.

By bringing together expertise across basic, translational, and clinical research, we aim to foster collaborative efforts that can drive therapeutic innovations. The conference will also offer a dedicated platform for young researchers to present their findings and engage with senior experts, further advancing the field.

Registration

Our objectives are

  • to investigate cardiac gene regulation and its role in disease.
  • to discuss innovative *in vitro* models for understanding cardiovascular health and disease.
  • to explore the potential of mRNA technologies in heart diagnostics and therapy.
  • to review differences of cardiac metabolism in heart failure subtypes (HFpEF vs HFrEF).
  • to examine inter-organ communication in heart failure.
  • to highlight emerging therapeutic approaches in cardiovascular health.

DGJM Organizing committee Heidelberg

Mirko Völkers

Arica Beisaw

Maarten van dem Hoogenhof

Christoph Hofmann

Vivien Kmietczyk

DGJM advice and program committee:

Gabriele Schiattarella (Berlin)

Pieterjan Dierickx (Bad Nauheim)

Monika Gladka (Amsterdam)

Diederik Kuster (Amsterdam)

Herman Silljé (Groningen)

Rabea Hinkel (Göttingen)

Program

12:00 – 12:45Arrival, lunch snack 
12:45 – 13:00 Welcome and Organizational Issues 
13:00 – 14:30 

Session 1: Gene regulatory mechanisms in cardiac diseases

Chairs: Esther Creemers (Amsterdam, NL), Maarten van den Hoogenhof (Heidelberg, DE)

Presentations:

  • Leon de Windt (Maastricht, NL)
  • Johannes Backs (Heidelberg, DE)
  • Vincent Christoffels (Amsterdam, NL)
  • Norbert Hübner (Berlin, DE)
14:30 – 16:00 

Poster Session Walk I 

Judges: Wolfgang Linke (Münster, DE), Katrin Streckfuß-Bömeke (Würzburg, DE), Toon van Veen (Utrecht, NL), Harsha Devalla (Amsterdam, NL)

16:00 –16:45 

Clinical translational lecture: Norbert Frey (Heidelberg, DE)

Heart failure: Novel targets for future therapies

16:45 – 17:15 Coffee Break
17:15-18:00

Session 2: mRNA in the heart- diagnostic tools and therapeutic potential

Presentations:

Chairs: Herman Sillje (Groningen, NL), Laura Zelarayán (Göttingen, DE)

  • Speaker 1: Anke Tijsen (Amsterdam, NL)
  • Speaker 2: Stefan Engelhardt (München, DE): Development of a macrophage-targeted RNA therapeutic.
17:15- 18:00Keynote lecture 1: Mauro Giacca, King's College London
20:00 Dinner and Evening event
9:30 – 11:30 

Session 3: Non-Animal Approaches to study CV development and disease 

Chairs: Diederik Kuster (Amsterdam, NL), Lucie Carrier (Hamburg, DE)

Presentations:

  • Verena Schwach (Twente, NL): Innovative cardiac models to study development and disease
  • Maike Frye (Hamburg, DE): Endothelial mechanoregulation in cardiovascular disease
  • Milena Belin (Leiden, NL): Cardiac microtissues from human pluripotent stem cells to model inherited heart diseases and to test drugs.
  • Malte Tiburcy, (Göttingen, DE): Cellular cross-talk in engineered human myocardium
11:30 – 12:00 Coffee Break
12:00 – 13:00 

Session 4: Intercellular/-organ communication in HF

Chairs: Pieterjan Diericks (Bad Nauheim, DE), Eva van Rooij (Utrecht, NL)

Presentations:

  • Dirk Duncker (Amsterdam, NL): Pathophysiology of Microvascular- and Diastolic Dysfunction in Swine with Diabetes, Dyslipidemia and Chronic Kidney Disease
  • Sabine Steffens (München, DE): Non-classical monocytes contribute to sex-differences in cardiac fibrosis
  • Laura Meems (Groningen, NL)
  • Maria-Patapia Zafeiriou (Göttingen, DE)
13.00 - 13.45 Lunch
13.45 – 14:30 

Poster Session Walk II 

Judges: Rabea Hinkel (Göttingen, DE), Lorenz Lehmann (Heidelberg, DE), Phil Barnett (Amsterdam, NL), Anke Smits (Leiden, NL)

14:30-16:00 

Session 5: Metabolic underpinnings of HF: HFpEF vs HFrEF

Chairs: Daan Westenbrink (Groningen, NL), Gabriele Schiattarella (Berlin, DE)

Presentations:

  • Deli Zhang (Wageningen, NL): Methods Spotlight: Assessing Mitochondrial (dys)function in Frozen Hearts
  • Christoph Maack (Würzburg): Mitochondrial redox regulation in heart failure
  • Miranda Nabben (Maastricht, NL)
  • Christian Oeing (Berlin, DE): Role of mTORC1 in HFpEF
16:00 – 16:30Coffee Break
16:30 – 18:00 

Session 6: Young Investigator Award Session (selected from abstracts)

Poster Judges: Kristina Lorenz (Würzburg, DE), Anke Smits (Leiden, NL), Wouter Meijers (Rotterdam, NL), Daniela Panakova (Kiel, DE)

Speaker 1: 
Speaker 2: 
Speaker 3: 
Speaker 4:

19:00 Diner, Evening event

 

 

 

9:00 – 10:30

Session 7: Cardiac Aging, regeneration and rejuvenation.

Chairs: Arica Beisaw (Heidelberg, DE), Kees Jan Boogerd (Utrecht, NL)

Presentations:

  • Jeroen Bakkers (Utrecht, NL): Interspecies comparison reveals a novel mechanism of cardiac regeneration.
  • Rabea Hinkel (Göttingen, DE):
  • Monika Gladka (Amsterdam, NL):
  • Johnny Kim (TRON, DE): Towards translation of cardiovascular reprogramming.
10:30 – 11:00Coffee Break
11:00 –11:45 2nd Keynote: Benjamin Prosser (University of Pennsylvania, USA)
11:45 – 12:30 Lunch Break
12:30 – 14:00

Session 8: Innovative therapeutic approaches in CVDs

Chairs: Thomas Eschenhagen (Hamburg, DE), Jolanda van der Velden (Amsterdam, NL)

Presentations:

  • Peter van der Meer (Groningen, NL):
  • Wolfram Zimmerman (Göttingen, DE): Remuscularization of the Primate and Human Heart.
  • Stephane Heymans (Maastricht, NL): Dilated cardiomyopathy: discovery of gene- and inflammation-specific targets.
  • Kristina Lorenz (Würzburg, DE):
14:00 YIA Winner and Poster Prize Announcement 
14.20 Announcement next year venue 
14:30 Departure

 

 

 

Venue

Address

Heidelberg University Hospital
Medical Clinic, Grand Auditorium
Im Neuenheimer Feld 410
69120 Heidelberg

Contact

Universitätsklinikum Heidelberg
Medizinische Klinik III 
Im Neuenheimer Feld 669
69120 Heidelberg

Contact Person:
 

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